EWSR1

Gene Symbol EWSR1
Entrez Gene 2130
Alt Symbol EWS, bK984G1.4
Species Human
Gene Type protein-coding
Description EWS RNA-binding protein 1
Other Description EWS RNA-binding protein variant 6|Ewing sarcoma breakpoint region 1|Ewings sarcoma EWS-Fli1 (type 1) oncogene|RNA-binding protein EWS
Swissprots Q96FE8 Q96MN4 Q01844 Q96MX4 Q92635 B0QYK1 Q9BWA2 Q5THL0
Accessions AAD15010 BAA31990 CAA51489 CAA69177 CAA70044 CAH33891 EAW59780 EAW59781 EAW59782 EAW59783 EAW59784 EAW59785 EAW59786 EAW59787 Q01844 AI564543 AK026270 AK056309 BAB71145 AK056681 BAB71252 AK096787 AK127624 AK225096 AK225102 AL833489 AW205707 BC000527 AAH00527 BC004817 AAH04817 BC011048 AAH11048 BC072442 AAH72442 BE741903 BM981230 BX648769 CR456490 CAG30376 CU013087 CAK54518 CU013375 CAK54817 CX786322 DA013931 DA051447 DB051511 DB443651 EU327511 ABY40719 JX977847 AGS36504 S62665 AAB27172 X66899 CAA47350 XM_005261389 XP_005261446 XM_005261390 XP_005261447 XM_011529995 XP_011528297 XM_011529996 XP_011528298 XM_011529997 XP_011528299 XM_011529998 XP_011528300 XM_011529999 XP_011528301 XM_011530000 XP_011528302 XM_011530001 XP_011528303 XM_011530002 XP_011528304 NM_001163285 NP_001156757 NM_001163286 NP_001156758 NM_001163287 NP_001156759 NM_005243 NP_005234 NM_013986 NP_053733
Function Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Subcellular Location Nucleus {ECO:0000269|PubMed:16965792}. Cytoplasm {ECO:0000269|PubMed:16965792}. Cell membrane {ECO:0000269|PubMed:16965792}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Tissue Specificity Ubiquitous.
Top Pathways Transcriptional misregulation in cancer

Rabbit anti-EWS Antibody, Affinity Purified - PLA0104 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-EWS Antibody, Affinity Purified: <B>Cat. No. PLA0104</B>: Detection of Human EWS by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma. Antibody: Affinity purified Rabbit Anti-EWS (<B>Cat. No. PLA0104</B>) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB

RNA-binding protein EWS (EWSR1), Human, ELISA Kit - CSB-EL007875HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Ewing sarcoma breakpoint region 1, ELISA Kit - MBS908129 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human EWSR1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 25 pg/ml -1600 pg/ml.

Human RNA-binding protein EWS(EWSR1) ELISA kit - CSB-EL007875HU from Cusabio

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

Human EWSR1 ELISA Kit - E013792 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human EWSR1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

anti-EWS / EWSR1 antibody - ARG64855 from Arigo Biolaboratories

Category ELISA Kit

EWSR1 ELISA Kit (Human) (OKCA01496) - OKCA01496 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 6.25 pg/mL
Range 25 - 1,600 pg/mL
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