Gene Symbol | PKD1L1 |
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Entrez Gene | 168507 |
Alt Symbol | PRO19563 |
Species | Human |
Gene Type | protein-coding |
Description | polycystic kidney disease 1 like 1 |
Other Description | PC1-like 1 protein|polycystic kidney disease protein 1-like 1|polycystin-1L1 |
Swissprots | Q8TDX9 Q6UWK1 |
Accessions | EAW61003 EAW61004 EAW61005 EAW61006 EAW61007 Q8TDX9 AB061683 BAB85807 AI860869 AY358757 AAQ89117 BF062285 CN283529 XM_011515163 XP_011513465 NM_138295 NP_612152 |
Function | Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO:0000269|PubMed:24336289}. |
Subcellular Location | Cell projection, cilium membrane {ECO:0000269|PubMed:24336289}; Multi-pass membrane protein {ECO:0000269|PubMed:24336289}. |
Tissue Specificity | Detected in testis and in fetal and adult heart. |
Polycystin-1L1 CRISPR/Cas9 KO Plasmid (h) - sc-414908 from Santa Cruz Biotechnology
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Polycystin-1L1 HDR Plasmid (h) - sc-414908-HDR from Santa Cruz Biotechnology
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Polycystin-1L1 Double Nickase Plasmid (h) - sc-414908-NIC from Santa Cruz Biotechnology
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Polycystin-1L1 Double Nickase Plasmid (h2) - sc-414908-NIC-2 from Santa Cruz Biotechnology
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Polycystin-1L1 CRISPR Activation Plasmid (h) - sc-414908-ACT from Santa Cruz Biotechnology
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Polycystin-1L1 CRISPR Activation Plasmid (h2) - sc-414908-ACT-2 from Santa Cruz Biotechnology
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Polycystin-1L1 Lentiviral Activation Particles (h) - sc-414908-LAC from Santa Cruz Biotechnology
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Polycystin-1L1 Lentiviral Activation Particles (h2) - sc-414908-LAC-2 from Santa Cruz Biotechnology
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Polycystin-1L1 siRNA (h) - sc-89442 from Santa Cruz Biotechnology
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Polycystin-1L1 shRNA Plasmid (h) - sc-89442-SH from Santa Cruz Biotechnology
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Polycystin-1L1 shRNA (h) Lentiviral Particles - sc-89442-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16854 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16854 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04834 from Sigma-Aldrich
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PKD1L1 siRNA (Human) - CRJ6074 from Cohesion Biosciences
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shRNA set against Human PKD1L1 (NM_138295.3) - SHH376356 from Creative biogene
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PKD1L1 shRNA Plasmid (Human) - CHJ6074 from Cohesion Biosciences
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PKD1L1 miRNA 3'UTR clone - MiUTR4H-TG06725 from Creative biogene
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