Gene Symbol | PKD1L1 |
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Entrez Gene | 168507 |
Alt Symbol | PRO19563 |
Species | Human |
Gene Type | protein-coding |
Description | polycystic kidney disease 1 like 1 |
Other Description | PC1-like 1 protein|polycystic kidney disease protein 1-like 1|polycystin-1L1 |
Swissprots | Q8TDX9 Q6UWK1 |
Accessions | EAW61003 EAW61004 EAW61005 EAW61006 EAW61007 Q8TDX9 AB061683 BAB85807 AI860869 AY358757 AAQ89117 BF062285 CN283529 XM_011515163 XP_011513465 NM_138295 NP_612152 |
Function | Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO:0000269|PubMed:24336289}. |
Subcellular Location | Cell projection, cilium membrane {ECO:0000269|PubMed:24336289}; Multi-pass membrane protein {ECO:0000269|PubMed:24336289}. |
Tissue Specificity | Detected in testis and in fetal and adult heart. |
Polycystin-1L1 (C-14) - sc-165259 from Santa Cruz Biotechnology
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Polycystin-1L1 (E-15) - sc-165260 from Santa Cruz Biotechnology
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Anti-PKD1L1 antibody - ab72269 from Abcam
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Anti-PKD1L1 antibody - ab72475 from Abcam
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Anti-PKD1L1 Antibody (aa63-112) - LS-C151167 from LifeSpan Bioscience
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PKD1L1 Antibody - NBP1-87220 from Novus Biologicals
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PKD1L1 Antibody - NBP1-87219 from Novus Biologicals
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PKD1L1 Antibody - NB100-98739 from Novus Biologicals
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Anti-PKD1L1 antibody produced in rabbit - HPA022424 from Sigma-Aldrich
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Anti-PKD1L1 antibody produced in rabbit - HPA020422 from Sigma-Aldrich
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PKD1L1 Antibody - N-terminal region (ARP65805_P050) - ARP65805_P050 from Aviva Systems Biology
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PKD1L1 Polyclonal Antibody - OSP00008W from Thermo Fisher Scientific
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PKD1L1 Polyclonal Antibody - OSP00013W from Thermo Fisher Scientific
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Anti-Polycystin-L Antibody - AB9084 from EMD Millipore
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PKD1L1 antibody - TA337921 from Acris Antibodies
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PKD1L1 Antibody,Biotin conjugated - CSB-PA823467LD01HU from Cusabio
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PKD1L1 Antibody,FITC conjugated - CSB-PA823467LC01HU from Cusabio
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PKD1L1 Antibody,HRP conjugated - CSB-PA823467LB01HU from Cusabio
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PKD1L1 Antibody - CSB-PA823467LA01HU from Cusabio
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Anti-PKD1L1 (cytoplasmic domain) polyclonal antibody - CABT-BL2907 from Creative Diagnostics
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Anti-PKD1L1 polyclonal antibody - CABT-BL2908 from Creative Diagnostics
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Anti-PKD1L1 Antibody A11313 - A11313 from Boster Bio
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PKD1L1 Antibody - N-terminal region : Biotin (ARP65805_P050-Biotin) - ARP65805_P050-Biotin from Aviva Systems Biology
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PKD1L1 Antibody - N-terminal region : FITC (ARP65805_P050-FITC) - ARP65805_P050-FITC from Aviva Systems Biology
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PKD1L1 Antibody - N-terminal region : HRP (ARP65805_P050-HRP) - ARP65805_P050-HRP from Aviva Systems Biology
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