SIRT4

Gene Symbol SIRT4
Entrez Gene 519328
Alt Symbol -
Species Bovine
Gene Type protein-coding
Description sirtuin 4
Other Description NAD-dependent deacetylase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4
Swissprots Q1JQC6
Accessions DAA20626 Q1JQC6 BC116055 AAI16056 GQ166650 ACS66700 XM_005217844 XP_005217901 XM_005217845 XP_005217902 XM_005217846 XP_005217903 XM_005217847 XP_005217904 XM_010813926 XP_010812228 NM_001075785 NP_001069253
Function Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161}.
Subcellular Location Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161}.

Anti-SIRT4 antibody - ab10140 from Abcam

Prices $382.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab10140 at 2.5µg/ml staining SIRT4 in human skeletal muscle tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded tissue sections). Tissue underwent antigen retrieval in steam in citrate buffer pH 6.0. AP staining procedure was used for detection.

Anti-SIRT4 antibody - ab105039 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT4 antibody (ab105039) at 1/250 dilution + Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SIRT4 antibody - ab90485 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT4 antibody (ab90485) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal small intestine lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SIRT4 antibody - ab197127 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SIRT4 antibody (ab197127) at 1/500 dilution + HepG2 lysate

Anti-SIRT4 antibody - ab168679 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SIRT4 antibody (ab168679) at 1 µg/mlLane 1 : SIRT4 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-SIRT4 antibody (HRP) - C-terminal - ab139128 from Abcam

Prices $376.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Anti-SIRT4 antibody (HRP) - C-terminal (ab139128) at 1/1000 dilution + Human kidney lysate in RIPA buffer at 35 µgdeveloped using the ECL technique
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