| Gene Symbol |
PYCR1
|
| Entrez Gene |
5831
|
| Alt Symbol |
ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pyrroline-5-carboxylate reductase 1
|
| Other Description |
P5C reductase 1|proliferation-inducing protein 45|pyrroline-5-carboxylate reductase 1, mitochondrial
|
| Swissprots |
Q6FHI4 Q9HBQ4 B4DMU0 A6NFM2 P32322 Q96DI6
|
| Accessions |
ADG28674 EAW89717 EAW89718 EAW89719 EAW89720 EAW89721 EAW89722 EAW89723 EAW89724 EAW89725 EAW89726 P32322 AA026075 AF218000 AAG17242 AK225879 AK297627 BAG60002 AK303852 BAH14067 AL561248 AY513285 AAT08038 BC001504 AAH01504 BC022244 AAH22244 BC071842 AAH71842 CR541769 CAG46568 DA521426 HQ154643 ADU15815 HQ154644 ADU15816 HQ447821 ADQ32305 JF432573 ADZ15790 M77836 AAA36407 XM_005256381 XP_005256438 XM_011523583 XP_011521885 XM_011523584 XP_011521886 XM_011523585 XP_011521887 NM_001282279 NP_001269208 NM_001282280 NP_001269209 NM_001282281 NP_001269210 NM_006907 NP_008838 NM_153824 NP_722546
|
| Function |
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:19648921}.
|
| Top Pathways |
Arginine and proline metabolism, Biosynthesis of amino acids
|