| Gene Symbol |
SPTSSB
|
| Entrez Gene |
165679
|
| Alt Symbol |
ADMP, C3orf57, SSSPTB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine palmitoyltransferase, small subunit B
|
| Other Description |
androgen down regulated in mouse prostate|likely ortholog of androgen down regulated gene expressed in mouse prostate|serine palmitoyltransferase small subunit B|small subunit of serine palmitoyltransferase B
|
| Swissprots |
D3DNM8 Q0P5S6 Q8NFR3 B2R5D3
|
| Accessions |
EAW78615 EAW78616 EAW78617 Q8NFR3 AF458592 AAM49720 AK123348 BAC85589 AK312144 BAG35080 BC037817 BC065208 AAH65208 BC071875 AAH71875 BC107756 AAI07757 BC126236 AAI26237 BC130565 BU950276 BU950567 XM_011512481 XP_011510783 XM_011512482 XP_011510784 NM_145035 NM_001040100 NP_001035189
|
| Function |
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction. {ECO:0000269|PubMed:19416851}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells. {ECO:0000269|PubMed:15777716}.
|