Gene Symbol | SPTSSB |
---|---|
Entrez Gene | 165679 |
Alt Symbol | ADMP, C3orf57, SSSPTB |
Species | Human |
Gene Type | protein-coding |
Description | serine palmitoyltransferase, small subunit B |
Other Description | androgen down regulated in mouse prostate|likely ortholog of androgen down regulated gene expressed in mouse prostate|serine palmitoyltransferase small subunit B|small subunit of serine palmitoyltransferase B |
Swissprots | D3DNM8 Q0P5S6 Q8NFR3 B2R5D3 |
Accessions | EAW78615 EAW78616 EAW78617 Q8NFR3 AF458592 AAM49720 AK123348 BAC85589 AK312144 BAG35080 BC037817 BC065208 AAH65208 BC071875 AAH71875 BC107756 AAI07757 BC126236 AAI26237 BC130565 BU950276 BU950567 XM_011512481 XP_011510783 XM_011512482 XP_011510784 NM_145035 NM_001040100 NP_001035189 |
Function | Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction. {ECO:0000269|PubMed:19416851}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells. {ECO:0000269|PubMed:15777716}. |