| Gene Symbol | Fasl |
|---|---|
| Entrez Gene | 14103 |
| Alt Symbol | APT1LG1, CD178, CD95-L, CD95L, Fas-L, Faslg, Tnfsf6, gld |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | Fas ligand (TNF superfamily, member 6) |
| Other Description | CD95 ligand|Fas antigen ligand|generalized lymphoproliferative disease|tumor necrosis factor ligand superfamily member 6 |
| Swissprots | P41047 Q61217 Q9R1F2 |
| Accessions | AAD14773 ABI24108 ABI24109 ABI24110 EDL39311 P41047 AF119335 AAD52106 AF288572 AAG60016 AK040139 BAC30520 AK141268 BAE24625 BC052866 AAH52866 DQ846747 ABI24111 S76752 AAB33780 U06948 AAA17800 U10984 AAA19778 U58995 AAB02915 XM_006496653 XP_006496716 XM_006496654 XP_006496717 NM_001205243 NP_001192172 NM_010177 NP_034307 |
| Function | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects (By similarity). {ECO:0000250}. |
| Subcellular Location | Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. |
| Top Pathways | Chagas disease (American trypanosomiasis), PI3K-Akt signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Herpes simplex infection, Proteoglycans in cancer |
FAS-L CRISPR/Cas9 KO Plasmid (m) - sc-420288 from Santa Cruz Biotechnology
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FAS-L HDR Plasmid (m) - sc-420288-HDR from Santa Cruz Biotechnology
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FAS-L Double Nickase Plasmid (m) - sc-420288-NIC from Santa Cruz Biotechnology
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FAS-L Double Nickase Plasmid (m2) - sc-420288-NIC-2 from Santa Cruz Biotechnology
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FAS-L CRISPR Activation Plasmid (m) - sc-420288-ACT from Santa Cruz Biotechnology
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FAS-L CRISPR Activation Plasmid (m2) - sc-420288-ACT-2 from Santa Cruz Biotechnology
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FAS-L Lentiviral Activation Particles (m) - sc-420288-LAC from Santa Cruz Biotechnology
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FAS-L Lentiviral Activation Particles (m2) - sc-420288-LAC-2 from Santa Cruz Biotechnology
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FAS-L siRNA (m) - sc-35358 from Santa Cruz Biotechnology
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FAS-L shRNA Plasmid (m) - sc-35358-SH from Santa Cruz Biotechnology
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FAS-L shRNA (m) Lentiviral Particles - sc-35358-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU026881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31185 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31185 from Sigma-Aldrich
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FASLG siRNA (Mouse) - CRM1309 from Cohesion Biosciences
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FASLG - MBS8210020 from MyBioSource
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shRNA set against Mouse Fasl (NM_010177.4) - SHH292489 from Creative biogene
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Mouse FASLG siRNA - orb280785 from Biorbyt
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FASLG shRNA Plasmid (Mouse) - CHM1309 from Cohesion Biosciences
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