Fasl

Gene Symbol Fasl
Entrez Gene 14103
Alt Symbol APT1LG1, CD178, CD95-L, CD95L, Fas-L, Faslg, Tnfsf6, gld
Species Mouse
Gene Type protein-coding
Description Fas ligand (TNF superfamily, member 6)
Other Description CD95 ligand|Fas antigen ligand|generalized lymphoproliferative disease|tumor necrosis factor ligand superfamily member 6
Swissprots P41047 Q61217 Q9R1F2
Accessions AAD14773 ABI24108 ABI24109 ABI24110 EDL39311 P41047 AF119335 AAD52106 AF288572 AAG60016 AK040139 BAC30520 AK141268 BAE24625 BC052866 AAH52866 DQ846747 ABI24111 S76752 AAB33780 U06948 AAA17800 U10984 AAA19778 U58995 AAB02915 XM_006496653 XP_006496716 XM_006496654 XP_006496717 NM_001205243 NP_001192172 NM_010177 NP_034307
Function Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects (By similarity). {ECO:0000250}.
Subcellular Location Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface.
Top Pathways Chagas disease (American trypanosomiasis), PI3K-Akt signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Herpes simplex infection, Proteoglycans in cancer

FAS-L (Kay-10) - sc-19988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAS-L (Kay-10): sc-19988. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lymphoma tissue showing membrane localization.

Anti-Fas Ligand antibody - ab18373 from Abcam

Prices $370.00
Sizes 500 µg
Host Hamster
Clonality Polyclonal

Anti-Fas Ligand antibody [MFL3] (Phycoerythrin) - ab93566 from Abcam

Prices $376.00
Sizes 50 µg
Clonality Monoclonal
Clone MFL3
Surface staining of mouse Fas Ligand transfected cells with 0.5µg ab93566. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Anti-Fas Ligand antibody [MFL3] - Low endotoxin, Azide free - ab171253 from Abcam

Prices $370.00
Sizes 100 µg
Clonality Monoclonal
Clone MFL3

Anti-Fas Ligand antibody [MFL4] - ab84605 from Abcam

Prices $359.00
Sizes 100 µg
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (A11) - NBP1-97519 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone A11
Immunohistochemistry-Paraffin: Fas Ligand Antibody (A11) [NBP1-97519] - Immunohistochemical localization of FasL in adult mouse testis using the A11 antibody.

Fas Ligand/TNFSF6 Antibody - AF526 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
In the presence of a cross-linking antibody, mouse anti-HA Monoclonal Antibody, Recombinant Mouse Fas Ligand/TNFSF6 (Catalog # 6128-SA) induces cytotoxicity in the Jurkat human acute T cell leukemia cell line in a dose-dependent manner (orange line). Under these conditions, cytotoxicity elicited by Recombinant Mouse Fas Ligand/TNFSF6 (10 ng/mL) is neutralized (green line) by increasing concen­trations of Goat Anti-Mouse Fas Ligand/TNFSF6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF526). The ND50 is typically 0.125‑0.75 µg/mL.

Fas Ligand/TNFSF6 Antibody - NBP1-45557 from Novus Biologicals

Prices $245.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Fas Ligand/TNFSF6 Antibody [NBP1-45557] - Analysis of FasL expression in rat kidney tissue lysate.

Fas Ligand/TNFSF6 Antibody (MFL4) - NBP1-43275 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone MFL4
Flow Cytometry: Fas Ligand Antibody (MFL4) [NBP1-43275] - See notes for image caption

Fas Ligand/TNFSF6 Antibody (Kay-10) - NB100-77497 from Novus Biologicals

Prices $329.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone Kay-10
Flow Cytometry: Fas Ligand Antibody (Kay-10) [NB100-77497] - Mouse Fas Ligand transfected cells stained with purified KAY-10, followed by biotinylated anti-mouse IgG and Sav-PE

Fas Ligand/TNFSF6 Antibody (MFL3) - NBP1-43276 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone MFL3
Flow Cytometry: Fas Ligand Antibody (MFL3) [NBP1-43276] - Surface staining of mouse Fas Ligand-transfected cells with Anti-Mouse CD178 (Fas Ligand) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Fas Ligand/TNFSF6 Antibody [Biotin] - BAF526 from Novus Biologicals

Prices $420.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Fas Ligand/TNFSF6 Antibody (H11) [Biotin] - NBP1-97621 from Novus Biologicals

Prices $269.00
Sizes 50 tests
Host Rat
Clonality Monoclonal
Clone H11
Immunocytochemistry/Immunofluorescence: Fas Ligand Antibody (H11) [Biotin] [NBP1-97621] - Detection of FasL in 293T cells transfected with a FasL expression vector. Method: Transfected cells were plated onto polylysine treated glass slides, fixed and permeabilized in methanol at -20C for 5 min, then in acetone at -20C for 30 sec. After 3 washes in PBS, 0.1% BSA, were incubated for 1 hr at room temperature with 20 ug/ml of biotinylated H11 antibody in PBS, 0.1% BSA. After rinsing in PBS, FITC-conjugated streptavidin was added for 30 min, slides washed again in PBS and visualized using a fluorescence microscope.

Fas Ligand/TNFSF6 Antibody (101624) [Allophycocyanin] - FAB526A from Novus Biologicals

Prices $339.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 101624
HEK293 human embryonic kidney cell line transfected with mouse Fas Ligand/TNFSF6 was stained with Rat Anti-Mouse Fas Ligand/TNFSF6 APC-conjugated Monoclonal Antibody (Catalog # FAB526A, filled histogram) or isotype control antibody (Catalog # IC005A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Fas Ligand/TNFSF6 Antibody (H11) [FITC] - NBP1-97649 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone H11
Flow Cytometry: Fas Ligand Antibody (H11) [FITC] [NBP1-97649] - Profile of 293T cells transiently transfected with a FasL-expression plasmid (filled profile). The open profile corresponds to mock-transfected 293T cells. Method: FasL-transfected 293T cells (5 x 10^5) were incubated on ice for 30 min in 50 ul FACS buffer (PBS, 5% Fetal calf serum, 0.02% azide) containing 1ug of FITC-labelled H11 antibody. After washing in FACS buffer, cells were anlyzed by flow cytometry. Do not exclude pre-apoptotic cells during data acquisition (see T. Renno, M. Hahne, J. Tschopp and H. R. MacDonald, J. Exp. Med., 183, 431 (1996)).

Fas Ligand/TNFSF6 Antibody (MFL4) [FITC] - NBP1-28810 from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4
Flow Cytometry: Fas Ligand Antibody (MFL4) [FITC] [NBP1-28810] - transfected cells with Hamster anti Mouse CD178:FITC

Fas Ligand/TNFSF6 Antibody (MFL4) [Allophycocyanin] - NBP1-43275APC from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [DyLight 350] - NBP1-43275UV from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [DyLight 680] - NBP1-43275FR from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [7C] - NBP1-43275V2 from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [DyLight 405] - NBP1-43275V from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [Alexa Fluor (R) 700] - NBP1-43275AF700 from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [Alexa Fluor (R) 647] - NBP1-43275AF647 from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [Alexa Fluor (R) 488] - NBP1-43275AF488 from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4

Fas Ligand/TNFSF6 Antibody (MFL4) [Alexa Fluor (R) 405] - NBP1-43275AF405 from Novus Biologicals

Host Hamster
Clonality Monoclonal
Clone MFL4
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