FHL2

Gene Symbol FHL2
Entrez Gene 2274
Alt Symbol AAG11, DRAL, FHL-2, SLIM-3, SLIM3
Species Human
Gene Type protein-coding
Description four and a half LIM domains 2
Other Description LIM domain protein DRAL|aging-associated gene 11|down-regulated in rhabdomyosarcoma LIM protein|four and a half LIM domains protein 2|skeletal muscle LIM-protein 3
Swissprots Q13229 Q2I5I4 Q14192 Q9P294 Q13644 Q5TM15
Accessions AAY14896 AAY15012 BAA92253 EAX01758 EAX01759 EAX01760 Q14192 AA758053 AB158503 BAD69710 AK097756 AK313841 BAG36573 AY634685 AAV35468 BC012742 AAH12742 BC014397 AAH14397 BC036085 BC093049 AAH93049 BI092736 BM836767 BP257466 BT006960 AAP35606 BX340370 CB989635 CF552311 CR457437 CAG33718 CR936682 CR936799 DQ266432 ABB73038 DQ307067 ABC25549 DQ896335 ABM87334 EU176424 ABW03875 JQ313902 AFH75080 L42176 AAA85333 U29332 AAC52073 U60117 AAC50794 XM_005263902 XP_005263959 XM_005263906 XP_005263963 XM_011510798 XP_011509100 XM_011510799 XP_011509101 XM_011510800 XP_011509102 NM_001039492 NP_001034581 NM_001450 NP_001441 NM_201555 NP_963849 NM_201557 NP_963851 NM_201556
Function May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11813260}.
Top Pathways Osteoclast differentiation

FHL-2 (A-6) - sc-374062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FHL-2 (A-6): sc-374062. Western blot analysis of FHL-2 expression in non-transfected: sc-117752 (A) and mouse FHL-2 transfected: sc-120254 (B) 293T whole cell lysates.

FHL-2 (E-8) - sc-398866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FHL-2 (E-8): sc-398866. Western blot analysis of FHL-2 expression in A-10 nuclear extract.

FHL-2 (F-1) - sc-393514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FHL-2 (F-1): sc-393514. Western blot analysis of FHL-2 expression in mouse heart tissue extract.

FHL-2 (C-16) - sc-13409 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FHL-2 (C-16): sc-13409. Western blot analysis of FHL-2 expression in non-transfected: sc-117752 (A) and mouse FHL-2 transfected: sc-120254 (B) 293T whole cell lysates.

FHL-2 (G-14) - sc-23179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FHL-2 (G-14): sc-23179. Western blot analysis of FHL-2 expression in mouse heart tissue extract.

FHL-2 (H-57) - sc-134472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FHL-2 (H-57): sc-134472. Western blot analysis of FHL-2 expression in rat heart (A) and mouse heart (B) tissue extracts.

FHL-2 (T-14) - sc-26316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FHL-2 (T-14): sc-26316. Western blot analysis of FHL-2 expression in non-transfected: sc-117752 (A) and mouse FHL-2 transfected: sc-120254 (B) 293T whole cell lysates.

FHL-2 (F4B2-B11) - sc-52667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
FHL-2 (F4B2-B11): sc-52667. Western blot analysis of FHL-2 expression in HeLa (A), A-10 (B) and Sol8 (C) nuclear extracts and rat heart (D) and mouse heart (E) tissue extracts.

Anti-FHL2 antibody - ab12327 from Abcam

Prices $392.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-FHL2 antibody - ab15715 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-FHL2 antibody (ab15715) at 1 µg/ml + Tissue lysates prepared from human heart at 35 µgdeveloped using the ECL technique

Anti-FHL2 antibody - ab58069 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
FHL2 antibody (ab58069) used in immunofluorescence at 1-5ug/ml on HeLa cells.

Anti-FHL2 antibody - ab56068 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-FHL2 antibody (ab56068) at 0.4 µg/mlLane 3 : Lane 1 : HeLa cell extract at 10ug/laneLane 2 : HeLa cell extract at 10ug/lane with 16 ug blocking peptideLane 3 : HeLa cell extract at 10ug/lane. Goat anti Rabbit HRP controlSecondarygoat anti-rabbit Ig HRP at 1/75000 dilutiondeveloped using the ECL technique

Anti-FHL2 Antibody (C-Terminus) - LS-C287230 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human FHL2 by Immunohistochemistry. Sample: FFPE sections of human breast carcinoma. Antibody: Affinity purified rabbit anti-FHL2 ( Lot2 - left and Lot1 - right) used at a dilution of 1:1000 (1 Detection: DAB.

Anti-FHL2 Antibody - LS-C26938 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of LS-C26938, rabbit polyclonal at 0.4 ug/ml on HeLa cell extract (10 ug/lane). Blots were developed with goat anti-rabbit Ig (1:75k) and Pierce Supersignal West Femto system. Lane: 1- X1847P at 0.4 ug/ml. 2- X1847P plus 16 ug blocking peptide. 3 - Goat anti Rabbit HRP control.

Anti-FHL2 Antibody (aa167-279) - LS-C66027 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FHL2 Antibody - LS-C121212 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FHL2 Antibody (aa199-248) - LS-C30542 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
FHL2 antibody LS-C30542 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

Anti-FHL2 Antibody - LS-C26926 from LifeSpan Bioscience

Prices $460.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of LS-C26926, rabbit polyclonal at 0.5 ug/ml on HeLa cell extract (10 ug/lane). Blots were developed with goat anti-rabbit Ig (1:75k) and Pierce Supersignal West Femto system.

Anti-FHL2 Antibody - LS-C178809 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-FHL2 Antibody (aa1-280, clone 10C237, Azide-free) - LS-C183623 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C237

Anti-FHL2 Antibody (aa175-225) - LS-C287229 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FHL2 Antibody - LS-C311144 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FHL2 Antibody (aa182-231) - LS-C81556 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-FHL2 Antibody (clone 11-134) - LS-C179576 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11-134

Anti-FHL2 Antibody - LS-C314099 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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