| Gene Symbol |
FHL2
|
| Entrez Gene |
2274
|
| Alt Symbol |
AAG11, DRAL, FHL-2, SLIM-3, SLIM3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
four and a half LIM domains 2
|
| Other Description |
LIM domain protein DRAL|aging-associated gene 11|down-regulated in rhabdomyosarcoma LIM protein|four and a half LIM domains protein 2|skeletal muscle LIM-protein 3
|
| Swissprots |
Q13229 Q2I5I4 Q14192 Q9P294 Q13644 Q5TM15
|
| Accessions |
AAY14896 AAY15012 BAA92253 EAX01758 EAX01759 EAX01760 Q14192 AA758053 AB158503 BAD69710 AK097756 AK313841 BAG36573 AY634685 AAV35468 BC012742 AAH12742 BC014397 AAH14397 BC036085 BC093049 AAH93049 BI092736 BM836767 BP257466 BT006960 AAP35606 BX340370 CB989635 CF552311 CR457437 CAG33718 CR936682 CR936799 DQ266432 ABB73038 DQ307067 ABC25549 DQ896335 ABM87334 EU176424 ABW03875 JQ313902 AFH75080 L42176 AAA85333 U29332 AAC52073 U60117 AAC50794 XM_005263902 XP_005263959 XM_005263906 XP_005263963 XM_011510798 XP_011509100 XM_011510799 XP_011509101 XM_011510800 XP_011509102 NM_001039492 NP_001034581 NM_001450 NP_001441 NM_201555 NP_963849 NM_201557 NP_963851 NM_201556
|
| Function |
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11813260}.
|
| Top Pathways |
Osteoclast differentiation
|