SH3KBP1

Gene Symbol SH3KBP1
Entrez Gene 30011
Alt Symbol CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18
Species Human
Gene Type protein-coding
Description SH3-domain kinase binding protein 1
Other Description CD2-binding protein 3|SH3 domain-containing kinase-binding protein 1|Src family kinase-binding protein 1|c-Cbl-interacting protein|cbl-interacting protein of 85 kDa|human Src family kinase-binding protein 1|migration-inducing gene 18|src-related kinase binding protein-1
Swissprots Q9NYR0 Q8IWX6 Q5JPT4 B7Z1D5 Q5JPT5 Q96RN4 Q8IX98 Q96B97
Accessions CAK32182 EAW98964 EAW98965 EAW98966 EAW98967 Q96B97 AF230904 AAF37854 AF329267 AAK95587 AF329268 AAO13348 AF542051 AAN77231 AK293234 BAH11470 AK293237 BAH11471 AK300189 BAH13234 AK307276 AK313308 BAG36113 AY423734 AAS00497 AY542305 AAT08174 BC015806 AAH15806 BC041055 BC050663 AAH50663 BP224209 DC359739 DC409010 DQ892387 ABM83313 DQ895600 ABM86526 DR000949 XM_005274494 XP_005274551 XM_011545498 XP_011543800 XM_011545499 XP_011543801 XM_011545500 XP_011543802 XM_011545501 XP_011543803 XM_011545502 XP_011543804 XM_011545503 XP_011543805 NM_001024666 NP_001019837 NM_001184960 NP_001171889 NM_031892 NP_114098
Function Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the contr
Subcellular Location Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Also expressed in some cancer cell lines.
Top Pathways Endocytosis

CIN85 (D1A4) Rabbit mAb - 12304 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1A4
Western blot analysis of extracts from various cell lines using CIN85 (D1A4) Rabbit mAb.

CIN85 (C-8) - sc-271567 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIN85 (C-8): sc-271567. Western blot analysis of CIN85 expression in Jurkat (A) and THP-1 (B) whole cell lysates.

CIN85 (E-1) - sc-377342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIN85 (E-1): sc-377342. Western blot analysis of CIN85 expression in non-transfected 293T: sc-117752 (A), human CIN85 transfected 293T: sc-175351 (B), THP-1 (C) and Jurkat (D) whole cell lysates.

CIN85 (A-7) - sc-166862 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIN85 (A-7): sc-166862. Western blot analysis of CIN85 expression in non-transfected: sc-117752 (A) and human CIN85 transfected: sc-175351 (B) 293T whole cell lysates.

CIN85 (H-300) - sc-48746 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CIN85 (H-300): sc-48746. Western blot analysis of CIN85 expression in Jurkat (A) and THP-1 (B) whole cell lysate.

CIN85 (G-12) - sc-271310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIN85 (G-12): sc-271310. Western blot analysis of CIN85 expression in non-transfected 293T: sc-117752 (A), human CIN85 transfected 293T: sc-175351 (B) and Jurkat (C) whole cell lysates.

CIN85 (S-19) - sc-22883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CIN85 (S-19): sc-22883. Western blot analysis of CIN85 expression in Jurkat (A) and THP-1 (B) whole cell lysate.

CIN85 (L-19) - sc-22881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CIN85 (L-19): sc-22881. Western blot analysis of CIN85 expression in non-transfected: sc-117752 (A) and human CIN85 transfected: sc-175351 (B) 293T whole cell lysates.

Anti-SH3KBP1 antibody - ab118581 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118581 at a concentration of 2.5 µg/ml.

Anti-SH3KBP1 antibody [EPR7880(2)] - ab154858 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7880(2)
All lanes : Anti-SH3KBP1 antibody [EPR7880(2)] (ab154858) at 1/1000 dilutionLane 1 : Human spleen tissue lysateLane 2 : Human fetal thymus tissue lysateLane 3 : Human fetal brain tissue lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-SH3KBP1 antibody [EPR7881(2)] - ab151574 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7881(2)
All lanes : Anti-SH3KBP1 antibody [EPR7881(2)] (ab151574) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : THP1 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-SH3KBP1 antibody - C-terminal - ab135370 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SH3KBP1 antibody - C-terminal (ab135370) at 1 µg/ml + Rat thymus tissue lysate at 10 µg

Anti-SH3KBP1 / CIN85 Antibody - LS-C17823 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-SH3KBP1 / CIN85 Antibody - LS-C17824 from LifeSpan Bioscience

Prices $530.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-SH3KBP1 / CIN85 Antibody - LS-C342247 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SH3KBP1 / CIN85 Antibody (aa107-156) - LS-C116580 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SH3KBP1 antibody LS-C116580 Western blot of Jurkat lysate.

Anti-SH3KBP1 / CIN85 Antibody (aa494-543) - LS-C151306 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SH3KBP1 / CIN85 antibody Western Blot of Rat Thymus.

Anti-SH3KBP1 / CIN85 Antibody (aa2-14) IHC-plus™ - LS-B5096 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SH3KBP1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5096 concentration 2.5 ug/ml.

CIN85/SH3KBP1 Antibody - NBP1-85614 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CIN85/SH3KBP1 Antibody [NBP1-85614] - Analysis in human cell line THP-1.

CIN85/SH3KBP1 Antibody - NBP1-57065 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SH3KBP1 Antibody [NBP1-57065] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

CIN85/SH3KBP1 Antibody - NBP1-85615 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CIN85/SH3KBP1 Antibody [NBP1-85615] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

Secretagogin Antibody (179.1.E1) - NBP2-29704 from Novus Biologicals

Prices $399.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 179.1.E1
Western Blot: Secretagogin Antibody (179.1.E1) [NBP2-29704] - NG108-15 cell lysate was probed with anti-SETA, clone 179.1.E1 (1ug/ml).

CIN85/SH3KBP1 Antibody - H00030011-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

SH3KBP1 Polyclonal Antibody - bs-16723R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SH3KBP1 Polyclonal Antibody - bs-6239R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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