| Gene Symbol | SH3KBP1 |
|---|---|
| Entrez Gene | 30011 |
| Alt Symbol | CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SH3-domain kinase binding protein 1 |
| Other Description | CD2-binding protein 3|SH3 domain-containing kinase-binding protein 1|Src family kinase-binding protein 1|c-Cbl-interacting protein|cbl-interacting protein of 85 kDa|human Src family kinase-binding protein 1|migration-inducing gene 18|src-related kinase binding protein-1 |
| Swissprots | Q9NYR0 Q8IWX6 Q5JPT4 B7Z1D5 Q5JPT5 Q96RN4 Q8IX98 Q96B97 |
| Accessions | CAK32182 EAW98964 EAW98965 EAW98966 EAW98967 Q96B97 AF230904 AAF37854 AF329267 AAK95587 AF329268 AAO13348 AF542051 AAN77231 AK293234 BAH11470 AK293237 BAH11471 AK300189 BAH13234 AK307276 AK313308 BAG36113 AY423734 AAS00497 AY542305 AAT08174 BC015806 AAH15806 BC041055 BC050663 AAH50663 BP224209 DC359739 DC409010 DQ892387 ABM83313 DQ895600 ABM86526 DR000949 XM_005274494 XP_005274551 XM_011545498 XP_011543800 XM_011545499 XP_011543801 XM_011545500 XP_011543802 XM_011545501 XP_011543803 XM_011545502 XP_011543804 XM_011545503 XP_011543805 NM_001024666 NP_001019837 NM_001184960 NP_001171889 NM_031892 NP_114098 |
| Function | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the contr |
| Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed. Also expressed in some cancer cell lines. |
| Top Pathways | Endocytosis |