SH3KBP1

Gene Symbol	SH3KBP1
Entrez Gene	30011
Alt Symbol	CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18
Species	Human
Gene Type	protein-coding
Description	SH3-domain kinase binding protein 1
Other Description	CD2-binding protein 3|SH3 domain-containing kinase-binding protein 1|Src family kinase-binding protein 1|c-Cbl-interacting protein|cbl-interacting protein of 85 kDa|human Src family kinase-binding protein 1|migration-inducing gene 18|src-related kinase binding protein-1
Swissprots	Q9NYR0 Q8IWX6 Q5JPT4 B7Z1D5 Q5JPT5 Q96RN4 Q8IX98 Q96B97
Accessions	CAK32182 EAW98964 EAW98965 EAW98966 EAW98967 Q96B97 AF230904 AAF37854 AF329267 AAK95587 AF329268 AAO13348 AF542051 AAN77231 AK293234 BAH11470 AK293237 BAH11471 AK300189 BAH13234 AK307276 AK313308 BAG36113 AY423734 AAS00497 AY542305 AAT08174 BC015806 AAH15806 BC041055 BC050663 AAH50663 BP224209 DC359739 DC409010 DQ892387 ABM83313 DQ895600 ABM86526 DR000949 XM_005274494 XP_005274551 XM_011545498 XP_011543800 XM_011545499 XP_011543801 XM_011545500 XP_011543802 XM_011545501 XP_011543803 XM_011545502 XP_011543804 XM_011545503 XP_011543805 NM_001024666 NP_001019837 NM_001184960 NP_001171889 NM_031892 NP_114098
Function	Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the contr
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Also expressed in some cancer cell lines.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SH3KBP1 full length protein - ab162311 from Abcam Category Protein Source Wheat germ Species Human

Human SH3KBP1 protein fragment - ab162312 from Abcam Category Protein Source Wheat germ Species Human

SH3KBP1 / CIN85 Antibody Blocking Peptide - LS-E19603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3KBP1 / CIN85 Antibody Blocking Peptide - LS-E19604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3KBP1 / CIN85 Antibody Blocking Peptide - LS-E25359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CIN85/SH3KBP1 Protein - H00030011-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CIN85/SH3KBP1 Recombinant Protein - H00030011-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SH3KBP1 Blocking Peptide - 33R-9090 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SH3KBP1 - H00030011-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SH3KBP1 - H00030011-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SH3KBP1 - H00030011-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SH3KBP1 - H00030011-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CIN85 fusion protein - ag2777 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SH3 domain-containing kinase-binding protein 1(SH3KBP1) - CSB-YP842640HU CSB-EP842640HU CSB-BP842640HU CSB-MP842640HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SH3KBP1 Protein - abx164110 from Abbexa Category Protein Species Human, Mouse, Rat

SH3KBP1 (transcript variant 1) - TP302186 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SH3KBP1 (transcript variant 2) - TP315701 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human SH3KBP1 protein (C-His) - orb312012 from Biorbyt Category Protein Prices $366.00, $629.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

CIN85/SH3KBP1 Protein - NBP1-85615PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

CIN85/SH3KBP1 Recombinant Protein Antigen - NBP1-85614PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SH3KBP1 Peptide, Human - M34GP14182H from Creative Peptides Category Peptide Source Synthetic. Species Human

SH3 domain-containing kinase-binding protein 1 (SH3KBP1), Recombinant Protein - MBS1315647 from MyBioSource Category Protein Prices $1,465.00, $1,465.00, $1,695.00, $1,695.00, $2,495.00, $2,495.00, $2,940.00, $2,940.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SH3KBP1, Recombinant Protein - MBS8249788 from MyBioSource Category Protein Prices $255.00, $635.00, $2,370.00 Sizes 10 µg, 50 µg, 500 µg Source Human cells Species Human

Human SH3KBP1 protein - orb392478 from Biorbyt Category Protein Species Human

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