| Gene Symbol |
NGF
|
| Entrez Gene |
4803
|
| Alt Symbol |
Beta-NGF, HSAN5, NGFB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nerve growth factor (beta polypeptide)
|
| Other Description |
beta-nerve growth factor|nerve growth factor, beta subunit
|
| Swissprots |
Q9P2Q8 P01138 Q9UKL8 Q96P60 A1A4E5 Q6FHA0
|
| Accessions |
AAA59931 AAD55975 BAA90437 CAA24755 EAW56629 P01138 AF411526 AAL05874 BC032517 AAH32517 BC126148 AAI26149 BC126150 AAI26151 BE045524 BT019733 AAV38538 CR541855 CAG46653 HQ258125 ADR82879 X52599 CAA36832 XM_006710663 XP_006710726 XM_006710665 XP_006710728 XM_011541518 XP_011539820 NM_002506 NP_002497
|
| Function |
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). {ECO:0000269|PubMed:20164177}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Apoptosis, MAPK signaling pathway, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Inflammatory mediator regulation of TRP channels
|
![Western Blot: NGF Overexpression Lysate (Adult Normal) [NBL1-13634] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NGF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8858_NGF%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13634-img0002.jpg)