| Gene Symbol |
SMARCA2
|
| Entrez Gene |
6595
|
| Alt Symbol |
BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
|
| Other Description |
ATP-dependent helicase SMARCA2|BAF190B|BRG1-associated factor 190B|SNF2-alpha|SNF2/SWI2-like protein 2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2|global transcription activator homologous sequence|probable global transcription activator SNF2L2|protein brahma homolog|sucrose nonfermenting 2-like protein 2
|
| Swissprots |
B1ALG4 D3DRH4 B1ALG3 D3DRH5 P51531
|
| Accessions |
AAB68685 EAW58811 EAW58812 EAW58813 EAW58814 EAW58815 P51531 AK094076 BAC04280 AK296373 BAG59047 AK298045 BAG60343 AK299683 BAG61590 AK300093 BAG61895 AK308941 AL558829 AY293824 BC040029 AAH40029 BC068252 BC156185 AAI56186 BI758293 BM921013 CA313181 CD107405 CD513892 CD702931 DA084762 DA823500 X72889 CAA51407 NM_001289396 NP_001276325 NM_001289397 NP_001276326 NM_001289398 NP_001276327 NM_001289399 NP_001276328 NM_001289400 NP_001276329 NM_003070 NP_003061 NM_139045 NP_620614
|
| Function |
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF
|
| Subcellular Location |
Nucleus.
|