SMARCA2

Gene Symbol SMARCA2
Entrez Gene 6595
Alt Symbol BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a
Species Human
Gene Type protein-coding
Description SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Other Description ATP-dependent helicase SMARCA2|BAF190B|BRG1-associated factor 190B|SNF2-alpha|SNF2/SWI2-like protein 2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2|global transcription activator homologous sequence|probable global transcription activator SNF2L2|protein brahma homolog|sucrose nonfermenting 2-like protein 2
Swissprots B1ALG4 D3DRH4 B1ALG3 D3DRH5 P51531
Accessions AAB68685 EAW58811 EAW58812 EAW58813 EAW58814 EAW58815 P51531 AK094076 BAC04280 AK296373 BAG59047 AK298045 BAG60343 AK299683 BAG61590 AK300093 BAG61895 AK308941 AL558829 AY293824 BC040029 AAH40029 BC068252 BC156185 AAI56186 BI758293 BM921013 CA313181 CD107405 CD513892 CD702931 DA084762 DA823500 X72889 CAA51407 NM_001289396 NP_001276325 NM_001289397 NP_001276326 NM_001289398 NP_001276327 NM_001289399 NP_001276328 NM_001289400 NP_001276329 NM_003070 NP_003061 NM_139045 NP_620614
Function Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF
Subcellular Location Nucleus.

BRM (D9E8B) XP ® Rabbit mAb - 11966 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9E8B
Western blot analysis of extracts from various cell lines using BRM (D9E8B) XP ® Rabbit mAb (upper) or Brg1 (A52) Antibody #3508 (lower).

BRM Antibody - 6889 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using BRM Antibody.

Brm (E-6) - sc-166579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Brm (E-6): sc-166579. Western blot analysis of Brm expression in K-562 (A) and THP-1 (B) nuclear extracts.

Brm (E-1) - sc-17828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Brm (E-1): sc-17828. Western blot analysis of Brm expression in HeLa (A), NIH/3T3 (B) and 3611-RF (C) whole cell lysates.

Brm (H-56) - sc-28710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Brm (H-56): sc-28710. Western blot analysis of Brm expression in U-937 (A) and THP-1 (B) nuclear extracts.

Brm (N-19) - sc-6450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Brm (N-19): sc-6450. Western blot analysis of Brm expression in HeLa (A) and K-562 (B) nuclear extracts.

Brm (24) - sc-135850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Brm (24): sc-135850. Western blot analysis of Brm expression in HeLa whole cell lysate.

Anti-SMARCA2 / BRM antibody - ab12165 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM antibody - ab58188 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58188 SMARCA2 / BRM antibody at 1ug/ml.

Anti-SMARCA2 / BRM antibody - ab12166 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM antibody [NONE] - C-terminal - ab200480 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NONE

Anti-SMARCA2 / BRM antibody - ChIP Grade - ab15597 from Abcam

Prices $403.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A) ab15597 specifically immunoprecipitates Brm. Immunoprecipitations were performed on bacculovirus–expressed Flag-tagged Brm and Brg1 from insect cells.  2µg of ab15597 (left hand side) and 2µg of J1 (right hand side) were used for each IP. J1 is a polyclonal antibody recognising both, Brg1 and Brm.B) ab15597 chromatin immunoprecipitates Brm. Two cell lines 1 and 2 were treated with different stimuli and subjected to the ChIP procedure. Cells were fixed with formaldehyde for 10mins. The ChIP was performed with 2µg of 15597 or J1 and 10µl of protein G Dynal beads. The immunoprecipitated DNA was quanified by real-time PCR with primers specific for genes A and B, respectively. J1 is a polyclonal antibody recognising both, Brg1 and Brm.

Anti-SMARCA2 / BRM Antibody (aa100-150) - LS-C89127 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1325-1375) - LS-C89128 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1-50) - LS-C89129 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (Gly264) - LS-C191295 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1-50) - LS-C287844 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa100-150) - LS-C287845 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1325-1375) - LS-C287846 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1-50, Agarose) - LS-C291138 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa100-150, Agarose) - LS-C291140 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa58-107) - LS-C30062 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SMARCA2 antibody LS-C30062 was used in IHC to stain formalin-fixed, paraffin-embedded human skin.

Anti-SMARCA2 / BRM Antibody (aa1325-1375, Agarose) - LS-C291144 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1387-1432) - LS-C313685 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCA2 / BRM Antibody (aa1328-1377) - LS-C199778 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from K562 cells, using Brm antibody.
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