Gene Symbol | ZFPM1 |
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Entrez Gene | 161882 |
Alt Symbol | FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger protein, FOG family member 1 |
Other Description | FOG-1|friend of GATA 1|friend of GATA protein 1|friend of GATA-1|zinc finger protein 89A|zinc finger protein ZFPM1|zinc finger protein, multitype 1 |
Swissprots | Q8IX07 |
Accessions | EAW66806 EAW66807 EAW66808 Q8IX07 AF488691 AAN45858 BE219988 XM_011522912 XP_011521214 XM_011522913 XP_011521215 XM_011522914 XP_011521216 XM_011522915 XP_011521217 XM_011522916 XP_011521218 XM_011522917 XP_011521219 XM_011522918 XP_011521220 NM_153813 NP_722520 |
Function | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. {ECO:0000269|PubMed:12483298}. |
FOG (A-6) - sc-376189 from Santa Cruz Biotechnology
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FOG (M-20) - sc-9361 from Santa Cruz Biotechnology
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FOG (R-18) - sc-9363 from Santa Cruz Biotechnology
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Anti-FOG1 antibody - ab84876 from Abcam
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Anti-FOG1 antibody - ab86281 from Abcam
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Anti-ZFPM1 / FOG1 Antibody (N-Terminus) - LS-C30123 from LifeSpan Bioscience
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Anti-ZFPM1 / FOG1 Antibody (aa755-804) - LS-C101379 from LifeSpan Bioscience
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Anti-ZFPM1 / FOG1 Antibody (aa935-984) - LS-C110461 from LifeSpan Bioscience
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Anti-ZFPM1 / FOG1 Antibody (aa175-225) - LS-C286605 from LifeSpan Bioscience
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Anti-ZFPM1 / FOG1 Antibody (aa175-225) - LS-C288226 from LifeSpan Bioscience
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ZFPM1 Antibody - NB100-68241 from Novus Biologicals
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ZNF408 Antibody - NBP1-82280 from Novus Biologicals
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ZFPM1 Antibody - 38140002 from Novus Biologicals
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FOG1 Polyclonal Antibody - bs-9451R from Bioss
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Anti-ZFPM1 antibody produced in rabbit - SAB2102773 from Sigma-Aldrich
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Anti-ZFPM1 antibody produced in rabbit - SAB2104440 from Sigma-Aldrich
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Anti-ZFPM1 antibody produced in rabbit - HPA046603 from Sigma-Aldrich
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ZFPM1 antibody - middle region (ARP32193_P050) - ARP32193_P050 from Aviva Systems Biology
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ZFPM1 antibody - middle region (ARP39961_P050) - ARP39961_P050 from Aviva Systems Biology
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ZFPM1-Antibody-C-term - AP21263b from Abgent, a WuXi AppTec company
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ZNF408 Antibody - abx029238 from Abbexa
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ZFPM1 / FOG1 antibody - H00161882-A01 from Acris Antibodies
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ZFPM1 Antibody - 25-050 from ProSci
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ZFPM1 Antibody - GWB-MN283D from Genway Biotech
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ZFPM1 Antibody - GWB-ML274D from Genway Biotech
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