| Gene Symbol |
ZFPM1
|
| Entrez Gene |
161882
|
| Alt Symbol |
FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein, FOG family member 1
|
| Other Description |
FOG-1|friend of GATA 1|friend of GATA protein 1|friend of GATA-1|zinc finger protein 89A|zinc finger protein ZFPM1|zinc finger protein, multitype 1
|
| Swissprots |
Q8IX07
|
| Accessions |
EAW66806 EAW66807 EAW66808 Q8IX07 AF488691 AAN45858 BE219988 XM_011522912 XP_011521214 XM_011522913 XP_011521215 XM_011522914 XP_011521216 XM_011522915 XP_011521217 XM_011522916 XP_011521218 XM_011522917 XP_011521219 XM_011522918 XP_011521220 NM_153813 NP_722520
|
| Function |
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. {ECO:0000269|PubMed:12483298}.
|