TNKS

Gene Symbol	TNKS
Entrez Gene	8658
Alt Symbol	ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
Species	Human
Gene Type	protein-coding
Description	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Other Description	ADP-ribosyltransferase diphtheria toxin-like 5|TANK1|TNKS-1|TRF1-interacting ankyrin-related ADP-ribose polymerase|poly [ADP-ribose] polymerase 5A|tankyrase I|tankyrase-1
Swissprots	Q4G0F2 O95271 O95272
Accessions	EAW65579 EAW65580 O95271 AB209339 BAD92576 AF070613 AF082556 AAC79841 AF082557 AAC79842 AF082558 AAC79843 AF082559 AAC79844 AK301798 BAG63250 AK302031 BAG63428 AK302534 BAG63806 AL706619 BC023578 BC098394 AAH98394 XM_006716263 XP_006716326 XM_011543845 XP_011542147 XM_011543846 XP_011542148 XM_011543847 XP_011542149 NM_003747 NP_003738
Function	Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:117397
Subcellular Location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere. Nucleus, nuclear pore complex. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.
Tissue Specificity	Ubiquitous; highest levels in testis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TNKS / Tankyrase ELISA Kit (Sandwich ELISA) - LS-F6498 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Tankyrase 1 Chemiluminescent Activity Assay - 4701-096-K from R&D Systems Category ELISA Kit Prices $1,067.00 Sizes 96 tests

Tankyrase 1 Colorimetric Activity Assay - 4700-192-K from R&D Systems Category ELISA Kit Prices $1,457.00 Sizes 192 tests

Tankyrase 1 Chemiluminescent Activity Assay - 4701-192-K from R&D Systems Category ELISA Kit Prices $1,457.00 Sizes 192 tests

Tankyrase 1 Colorimetric Activity Assay - 4700-096-K from R&D Systems Category ELISA Kit Prices $1,067.00 Sizes 96 tests

Tankyrase 1 (TNKS1), Human, ELISA Kit - SEC986Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.106ng/mL Range 0.312-20ng/mL

Tankyrase 1, TNKS1, Human, ELISA Kit - E-EL-H2418 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Tankyrase 1, TNKS1, Rabbit, ELISA Kit - E-EL-RB1535 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tankyrase 1, TNKS1, Chicken, ELISA Kit - E-EL-Ch1606 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Tankyrase 1, TNKS1, Porcine, ELISA Kit - E-EL-P1618 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tankyrase 1, TNKS1, Sheep, ELISA Kit - E-EL-S0217 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Tankyrase 1, TNKS1, Monkey, ELISA Kit - E-EL-MK1645 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human TNKS1(Tankyrase 1) ELISA Kit - E-EL-H2418 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human TNKS1 (Tankyrase 1) CLIA Kit - E-CL-H1420 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, ELISA Kit - MBS9318040 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TNKS1, ELISA Kit - MBS2515476 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

TNKS1, ELISA Kit - MBS2515251 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

TNKS1, ELISA Kit - MBS2508628 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

TNKS1, ELISA Kit - MBS2504799 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

TNKS1, ELISA Kit - MBS2514536 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

TNKS1, ELISA Kit - MBS2514055 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

ELISA Kit for Tankyrase 1 (TNKS1) - SEC986Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Tankyrase 1 (TNKS1) - SEC986Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human TNKS1(Tankyrase 1) ELISA Kit - E-EL-H2418 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mLng/mL Range 0.31~20 ng/mL

Human TNKS / Tankyrase ELISA Kit (Sandwich ELISA) - LS-F22200 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.188 ng/ml Range 0.313-20 ng/ml

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