| Gene Symbol |
TNKS
|
| Entrez Gene |
8658
|
| Alt Symbol |
ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
|
| Other Description |
ADP-ribosyltransferase diphtheria toxin-like 5|TANK1|TNKS-1|TRF1-interacting ankyrin-related ADP-ribose polymerase|poly [ADP-ribose] polymerase 5A|tankyrase I|tankyrase-1
|
| Swissprots |
Q4G0F2 O95271 O95272
|
| Accessions |
EAW65579 EAW65580 O95271 AB209339 BAD92576 AF070613 AF082556 AAC79841 AF082557 AAC79842 AF082558 AAC79843 AF082559 AAC79844 AK301798 BAG63250 AK302031 BAG63428 AK302534 BAG63806 AL706619 BC023578 BC098394 AAH98394 XM_006716263 XP_006716326 XM_011543845 XP_011542147 XM_011543846 XP_011542148 XM_011543847 XP_011542149 NM_003747 NP_003738
|
| Function |
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:117397
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere. Nucleus, nuclear pore complex. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.
|
| Tissue Specificity |
Ubiquitous; highest levels in testis.
|