TNKS

Gene Symbol	TNKS
Entrez Gene	8658
Alt Symbol	ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5
Species	Human
Gene Type	protein-coding
Description	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Other Description	ADP-ribosyltransferase diphtheria toxin-like 5|TANK1|TNKS-1|TRF1-interacting ankyrin-related ADP-ribose polymerase|poly [ADP-ribose] polymerase 5A|tankyrase I|tankyrase-1
Swissprots	Q4G0F2 O95271 O95272
Accessions	EAW65579 EAW65580 O95271 AB209339 BAD92576 AF070613 AF082556 AAC79841 AF082557 AAC79842 AF082558 AAC79843 AF082559 AAC79844 AK301798 BAG63250 AK302031 BAG63428 AK302534 BAG63806 AL706619 BC023578 BC098394 AAH98394 XM_006716263 XP_006716326 XM_011543845 XP_011542147 XM_011543846 XP_011542148 XM_011543847 XP_011542149 NM_003747 NP_003738
Function	Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:117397
Subcellular Location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere. Nucleus, nuclear pore complex. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.
Tissue Specificity	Ubiquitous; highest levels in testis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Tankyrase protein fragment - ab198639 from Abcam Category Protein Prices $1,281.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Tankyrase protein fragment - ab112380 from Abcam Category Protein Source Wheat germ Species Human

TNKS / Tankyrase Antibody Blocking Peptide - LS-E3666 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNKS / Tankyrase Antibody Blocking Peptide - LS-E11942 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNKS / Tankyrase Antibody Blocking Peptide - LS-E11943 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNKS / Tankyrase Antibody Blocking Peptide - LS-E12021 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Tankyrase 1 Peptide - NB100-186PEP from Novus Biologicals Category Peptide Prices $99.00 Sizes 50 µg

Recombinant Human Tankyrase 1 Protein - H00008658-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TNKS-Antibody-N-term-Blocking-Peptide - BP14867a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Tankyrase blocking peptide - GTX88517-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TNKS Blocking Peptide - 33R-9799 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TNKS Blocking Peptide - 33R-5048 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Tankyrase-1 (TANK1) - H00008658-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Tankyrase-1 (TANK1) - H00008658-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TNKS Peptide - 42-019P from ProSci Category Peptide Species Human

TNKS fusion protein - Ag12597 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TNKS protein, GST-tagged - TNKS-3328H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human TNKS, GST-tagged - TNKS-3327H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human TNKS - TNKS-31498TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Tankyrase 1 (TNKS1) - RPC986Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Tankyrase 1 (TNKS1) - RPC986Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Tankyrase-1(TNKS) ,partial - CSB-YP024004HU CSB-EP024004HU CSB-BP024004HU CSB-MP024004HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Tankyrase-1 (TNKS), partial, Recombinant Protein - MBS1040327 from MyBioSource Category Protein Prices $735.00, $855.00, $990.00, $990.00, $1,080.00, $1,150.00, $1,240.00, $1,260.00, $1,305.00, $1,540.00, $1,810.00, $1,880.00, $1,980.00, $2,410.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Tnks-Blocking-Peptide-C-term - BP5358b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Tnks-Blocking-Peptide-N-term - BP5357a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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