| Gene Symbol |
PNPT1
|
| Entrez Gene |
87178
|
| Alt Symbol |
COXPD13, DFNB70, OLD35, PNPASE, old-35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polyribonucleotide nucleotidyltransferase 1
|
| Other Description |
3'-5' RNA exonuclease OLD35|PNPase 1|PNPase old-35|polynucleotide phosphorylase 1|polynucleotide phosphorylase-like protein|polyribonucleotide nucleotidyltransferase 1, mitochondrial
|
| Swissprots |
Q9BVX0 Q7Z7D1 Q53SU0 Q68CN1 Q9BRU3 Q8IWX1 Q96T05 Q8TCS8
|
| Accessions |
AAY24271 CAR80228 CBX83686 EAX00086 EAX00087 Q8TCS8 AJ458465 CAD30289 AK307589 AW731791 AY027528 AAK13047 AY290863 AAP44472 BC000862 AAH00862 BC005986 AAH05986 BC009057 BC021170 BC053660 AAH53660 BU943827 CR749867 CAH18709 DA998523 DB461021 XM_005264629 XP_005264686 XM_011533142 XP_011531444 NM_033109 NP_149100
|
| Function |
RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double- stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-m
|
| Subcellular Location |
Cytoplasm. Mitochondrion. Mitochondrion intermembrane space; Peripheral membrane protein.
|
| Top Pathways |
RNA degradation, Purine metabolism, Pyrimidine metabolism
|