PNPT1

Gene Symbol	PNPT1
Entrez Gene	87178
Alt Symbol	COXPD13, DFNB70, OLD35, PNPASE, old-35
Species	Human
Gene Type	protein-coding
Description	polyribonucleotide nucleotidyltransferase 1
Other Description	3'-5' RNA exonuclease OLD35|PNPase 1|PNPase old-35|polynucleotide phosphorylase 1|polynucleotide phosphorylase-like protein|polyribonucleotide nucleotidyltransferase 1, mitochondrial
Swissprots	Q9BVX0 Q7Z7D1 Q53SU0 Q68CN1 Q9BRU3 Q8IWX1 Q96T05 Q8TCS8
Accessions	AAY24271 CAR80228 CBX83686 EAX00086 EAX00087 Q8TCS8 AJ458465 CAD30289 AK307589 AW731791 AY027528 AAK13047 AY290863 AAP44472 BC000862 AAH00862 BC005986 AAH05986 BC009057 BC021170 BC053660 AAH53660 BU943827 CR749867 CAH18709 DA998523 DB461021 XM_005264629 XP_005264686 XM_011533142 XP_011531444 NM_033109 NP_149100
Function	RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double- stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-m
Subcellular Location	Cytoplasm. Mitochondrion. Mitochondrion intermembrane space; Peripheral membrane protein.
Top Pathways	RNA degradation, Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PNPT1 full length protein - ab164775 from Abcam Category Protein Source Wheat germ Species Human

Human PNPT1 full length protein - ab202628 from Abcam Category Protein Source E. coli Species Human

PNPT1 Antibody Blocking Peptide - LS-E5137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNPT1 Antibody Blocking Peptide - LS-E15070 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNPT1 Recombinant Protein - H00087178-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PNPT1-Antibody-Center-Blocking-Peptide - BP17563c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PNPT1 Peptide - orb224334 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

PNPT1 Blocking Peptide - 33R-1698 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PNPT1 protein (His tag) - 80R-4158 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

PNPT1 (46-783, His-tag) - AR51844PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

PNPT1 (46-783, His-tag) - AR51844PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

PNPT1 - H00087178-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PNPT1 - H00087178-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PNPT1 fusion protein - Ag5888 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PNPT1 fusion protein - Ag6290 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PNPT1, GST-tagged - PNPT1-1821H from Creative Biomart Category Protein Source E.coli Species Human

PNPT1 Blocking Peptide - CBP3448 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Human Polyribonucleotide nucleotidyltransferase 1, mitochondrial(PNPT1) - CSB-YP840567HU CSB-EP840567HU CSB-BP840567HU CSB-MP840567HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PNPT1, 46-783aa, Human, His tag, E.coli - ATGP3024 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

PNPT1, Recombinant Protein - MBS206022 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 20 µg, 100 µg Source E Coli Species Human

Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1), Recombinant Protein - MBS1306242 from MyBioSource Category Protein Prices $1,550.00, $1,550.00, $1,775.00, $1,775.00, $2,665.00, $2,665.00, $3,105.00, $3,105.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PNPT1 Recombinant Protein Antigen - NBP2-38211PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PNPT1 Recombinant Protein Antigen - NBP1-82485PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PNPT1 Blocking Peptide - abx162310 from Abbexa Category Peptide Species Human, Mouse

PNPT1 Peptide, Human - M34GP12045H from Creative Peptides Category Peptide Source Synthetic. Species Human

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