ZPR1

Gene Symbol ZPR1
Entrez Gene 8882
Alt Symbol ZNF259
Species Human
Gene Type protein-coding
Description ZPR1 zinc finger
Other Description zinc finger protein 259|zinc finger protein ZPR1
Swissprots Q2TAA0 O75312
Accessions EAW67267 EAW67268 O75312 AF019767 AAC33514 AK301227 BAG62800 BC004256 AAH04256 BC011929 BC012162 AAH12162 BC017349 AAH17349 BC017380 AAH17380 BC111028 AAI11029 BT006642 AAP35288 NM_003904 NP_003895
Function Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766}.
Subcellular Location Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum- starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytopla
Tissue Specificity Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients. {ECO:0000269|PubMed:22422766}.

ZPR1 (LG1) Mouse mAb - 2014 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone LG1
Western blot analysis of extracts from various cell types using ZPR1 (LG1) Mouse mAb.

ZPR1 (B-12) - sc-398491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZPR1 (B-12): sc-398491. Western blot analysis of ZPR1 expression in non-transfected 293T: sc-117752 (A), mouse ZPR1 transfected 293T: sc-124831 (B), NIH/3T3 (C) and MCF7 (D) whole cell lysates.

ZPR1 (C-1) - sc-398241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZPR1 (C-1): sc-398241. Western blot analysis of ZPR1 expression in non-transfected 293T: sc-117752 (A), mouse ZPR1 transfected 293T: sc-124831 (B), NIH/3T3 (C), Jurkat (D), MCF7 (E) and A-431 (F) whole cell lysates.

ZPR1 (D-3) - sc-390125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZPR1 (D-3): sc-390125. Western blot analysis of ZPR1 expression in MIA PaCa-2 whole cell lysate.

ZPR1 (LG1) - sc-53554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ZPR1 (LG1): sc-53554. Western blot analysis of ZPR1 expression in non-transfected: sc-117752 (A) and mouse ZPR1 transfected: sc-124831 (B) 293T whole cell lysates.

ZPR1 (H-213) - sc-292973 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ZPR1 (C-20) - sc-6140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ZPR1 (C-20): sc-6140. Western blot analysis of ZPR1 expression in non-transfected: sc-117752 (A) and mouse ZPR1 transfected: sc-124831 (B) 293T whole cell lysates.

Anti-ZNF259 antibody - ab96652 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ZNF259 antibody (ab96652) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-ZNF259 antibody - ab170024 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ZNF259 antibody (ab170024) at 1/500 dilution + HepG2 cell lysate

Anti-ZNF259 antibody - ab56419 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ZNF259 antibody (ab56419) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-ZNF259 antibody - ab50666 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ZNF259 antibody (ab50666) at 0.03 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG (1:100,000)

Anti-ZNF259 antibody [EPR7595] - ab134970 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7595
All lanes : Anti-ZNF259 antibody [EPR7595] (ab134970) at 1/1000 dilutionLane 1 : Human stomach lysateLane 2 : Human fetal liver lysateLane 3 : Human colon cancer lysateLane 4 : BxPC3 lysateLane 5 : HepG2 lysateLane 6 : Caco2 lysateLane 7 : MCF7 lysateLane 8 : Jurkat lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ZNF259 antibody [LG1] - ab171117 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone LG1
Immunofluorescence analysis of formaldehyde-fixed mouse NIH 3T3 cells, probed without (control, right panel) or with ab171117 (left panel) labeling ZNF259 (green) at a 1/20 dilution overnight. Slides were washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. F-Actin was stained with Phalloidin (red) and nuclei with DAPI (blue).

Anti-ZPR1 / ZNF259 Antibody (aa405-434, FITC) - LS-C218504 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (aa405-434, AP) - LS-C218505 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (N-Terminus) - LS-C30214 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-ZPR1 / ZNF259 Antibody (C-Terminus) - LS-C30238 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-ZPR1 / ZNF259 Antibody (aa405-434, APC) - LS-C218506 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (aa405-434, Azide-free, HRP) - LS-C218508 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (aa405-434, PE) - LS-C218509 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (aa405-434, Biotin) - LS-C218507 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (aa404-434) - LS-C326564 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZPR1 / ZNF259 Antibody (aa361-460, Azide-free) - LS-C329143 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ZPR1 Antibody (Internal, clone EPR7595) - LS-C154743 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7595
IHC of paraffin embedded human colon tissue using anti-ZNF259 antibody.

Anti-ZPR1 / ZNF259 Antibody (clone 6F7) - LS-C133096 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6F7
Immunoperoxidase of monoclonal antibody to ZNF259 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
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