ZPR1
| Gene Symbol | ZPR1 |
|---|---|
| Entrez Gene | 8882 |
| Alt Symbol | ZNF259 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ZPR1 zinc finger |
| Other Description | zinc finger protein 259|zinc finger protein ZPR1 |
| Swissprots | Q2TAA0 O75312 |
| Accessions | EAW67267 EAW67268 O75312 AF019767 AAC33514 AK301227 BAG62800 BC004256 AAH04256 BC011929 BC012162 AAH12162 BC017349 AAH17349 BC017380 AAH17380 BC111028 AAI11029 BT006642 AAP35288 NM_003904 NP_003895 |
| Function | Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766}. |
| Subcellular Location | Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum- starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytopla |
| Tissue Specificity | Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients. {ECO:0000269|PubMed:22422766}. |
ZPR1 CRISPR/Cas9 KO Plasmid (h) - sc-409727 from Santa Cruz Biotechnology
|
||||||||
ZPR1 HDR Plasmid (h) - sc-409727-HDR from Santa Cruz Biotechnology
|
||||||||
ZPR1 Double Nickase Plasmid (h) - sc-409727-NIC from Santa Cruz Biotechnology
|
||||||||
ZPR1 Double Nickase Plasmid (h2) - sc-409727-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ZPR1 CRISPR Activation Plasmid (h) - sc-409727-ACT from Santa Cruz Biotechnology
|
||||||||
ZPR1 CRISPR Activation Plasmid (h2) - sc-409727-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ZPR1 Lentiviral Activation Particles (h) - sc-409727-LAC from Santa Cruz Biotechnology
|
||||||||
ZPR1 Lentiviral Activation Particles (h2) - sc-409727-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ZPR1 siRNA (h) - sc-35282 from Santa Cruz Biotechnology
|
||||||||
ZPR1 shRNA Plasmid (h) - sc-35282-SH from Santa Cruz Biotechnology
|
||||||||
ZPR1 shRNA (h) Lentiviral Particles - sc-35282-V from Santa Cruz Biotechnology
|
||||||||
ZNF259 RNAi - H00008882-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU111631 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN23343 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23343 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03715 from Sigma-Aldrich
|
||||||||
ZPR1 siRNA (Human) - CRH5869 from Cohesion Biosciences
|
||||||||
ZPR1 - MBS8225495 from MyBioSource
|
||||||||
shRNA set against Human ZNF259 (NM_003904.3) - SHH453444 from Creative biogene
|
||||||||
ZPR1 shRNA Plasmid (Human) - CHH5869 from Cohesion Biosciences
|
||||||||
ZNF259 miRNA 3'UTR clone - MiUTR1H-11538 from Creative biogene
|