ZPR1

Gene Symbol	ZPR1
Entrez Gene	8882
Alt Symbol	ZNF259
Species	Human
Gene Type	protein-coding
Description	ZPR1 zinc finger
Other Description	zinc finger protein 259|zinc finger protein ZPR1
Swissprots	Q2TAA0 O75312
Accessions	EAW67267 EAW67268 O75312 AF019767 AAC33514 AK301227 BAG62800 BC004256 AAH04256 BC011929 BC012162 AAH12162 BC017349 AAH17349 BC017380 AAH17380 BC111028 AAI11029 BT006642 AAP35288 NM_003904 NP_003895
Function	Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766}.
Subcellular Location	Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum- starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytopla
Tissue Specificity	Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients. {ECO:0000269|PubMed:22422766}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ZNF259 full length protein - ab132539 from Abcam Category Protein Source Wheat germ Species Human

ZPR1 Antibody Blocking Peptide - LS-E4461 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZPR1 Antibody Blocking Peptide - LS-E13794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZPR1 Antibody Blocking Peptide - LS-E13793 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ZNF259 Protein - H00008882-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ZNF259 Protein - H00008882-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ZNF259-Antibody-C-term-Blocking-Peptide - BP16777b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZNF259 Blocking Peptide - 33R-7252 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZNF259 Blocking Peptide - 33R-3458 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZNF259 - H00008882-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZNF259 - H00008882-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZNF259 - H00008882-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZNF259 - H00008882-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ZNF259 fusion protein - Ag8312 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ZNF259 fusion protein - Ag7980 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Zinc Finger Protein 259, GST-Tagged - ZNF259-6943H from Creative Biomart Category Protein

Recombinant Human Zinc Finger Protein 259, His-tagged - ZNF259-6944H from Creative Biomart Category Protein

Recombinant Human Zinc Finger Protein 259, GST-Tagged - ZNF259-6945H from Creative Biomart Category Protein

Recombinant Human Zinc Finger Protein 259, GST-Tagged - ZNF259-6946H from Creative Biomart Category Protein

Recombinant Human ZNF259, His-tagged - ZNF259-30759TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human ZNF259, His-tagged - ZNF259-3830H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Zinc finger protein ZPR1(ZNF259) - CSB-YP026617HU CSB-EP026617HU CSB-BP026617HU CSB-MP026617HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ZNF259 - TP305721 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Zinc finger protein ZPR1 (ZNF259) , Recombinant Protein - MBS1032205 from MyBioSource Category Protein Prices $2,015.00, $2,015.00, $2,480.00, $2,480.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZNF259 Protein - NBP2-38172PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

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