| Gene Symbol |
ZFYVE28
|
| Entrez Gene |
57732
|
| Alt Symbol |
LST2, LYST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, FYVE domain containing 28
|
| Other Description |
hLst2|lateral signaling target protein 2 homolog|zinc finger FYVE domain-containing protein 28
|
| Swissprots |
E9PG77 E9PB64 B7Z2G9 B7ZB19 B7Z1Q7 B2RP83 B7Z2M2 Q9HCC9 B3KX50 E9PB54 Q7Z6J3
|
| Accessions |
EAW82528 EAW82529 Q9HCC9 AB046863 BAB13469 AK126692 BAG54362 AK293775 BAH11593 AK294710 BAH11855 AK294874 BAH11908 AK316484 BAH14855 BC032605 BC035793 BC041866 AAH41866 BC053664 AAH53664 BC137309 AAI37310 BC137310 AAI37311 BM128958 XM_006713900 XP_006713963 XM_006713901 XP_006713964 XM_006713902 XP_006713965 XM_006713903 XP_006713966 XM_006713904 XP_006713967 XM_011513539 XP_011511841 XM_011513540 XP_011511842 XM_011513541 XP_011511843 NM_001172656 NP_001166127 NM_001172657 NP_001166128 NM_001172658 NP_001166129 NM_001172659 NP_001166130 NM_001172660 NP_001166131 NM_020972 NP_066023
|
| Function |
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:19460345}. Early endosome membrane {ECO:0000269|PubMed:19460345}. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.
|