Gene Symbol | ZFYVE28 |
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Entrez Gene | 57732 |
Alt Symbol | LST2, LYST2 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger, FYVE domain containing 28 |
Other Description | hLst2|lateral signaling target protein 2 homolog|zinc finger FYVE domain-containing protein 28 |
Swissprots | E9PG77 E9PB64 B7Z2G9 B7ZB19 B7Z1Q7 B2RP83 B7Z2M2 Q9HCC9 B3KX50 E9PB54 Q7Z6J3 |
Accessions | EAW82528 EAW82529 Q9HCC9 AB046863 BAB13469 AK126692 BAG54362 AK293775 BAH11593 AK294710 BAH11855 AK294874 BAH11908 AK316484 BAH14855 BC032605 BC035793 BC041866 AAH41866 BC053664 AAH53664 BC137309 AAI37310 BC137310 AAI37311 BM128958 XM_006713900 XP_006713963 XM_006713901 XP_006713964 XM_006713902 XP_006713965 XM_006713903 XP_006713966 XM_006713904 XP_006713967 XM_011513539 XP_011511841 XM_011513540 XP_011511842 XM_011513541 XP_011511843 NM_001172656 NP_001166127 NM_001172657 NP_001166128 NM_001172658 NP_001166129 NM_001172659 NP_001166130 NM_001172660 NP_001166131 NM_020972 NP_066023 |
Function | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:19460345}. Early endosome membrane {ECO:0000269|PubMed:19460345}. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated. |
ZFYVE28 CRISPR/Cas9 KO Plasmid (h) - sc-412894 from Santa Cruz Biotechnology
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ZFYVE28 HDR Plasmid (h) - sc-412894-HDR from Santa Cruz Biotechnology
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ZFYVE28 Double Nickase Plasmid (h) - sc-412894-NIC from Santa Cruz Biotechnology
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ZFYVE28 Double Nickase Plasmid (h2) - sc-412894-NIC-2 from Santa Cruz Biotechnology
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ZFYVE28 CRISPR Activation Plasmid (h) - sc-412894-ACT from Santa Cruz Biotechnology
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ZFYVE28 CRISPR Activation Plasmid (h2) - sc-412894-ACT-2 from Santa Cruz Biotechnology
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ZFYVE28 Lentiviral Activation Particles (h) - sc-412894-LAC from Santa Cruz Biotechnology
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ZFYVE28 Lentiviral Activation Particles (h2) - sc-412894-LAC-2 from Santa Cruz Biotechnology
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ZFYVE28 siRNA (h) - sc-89030 from Santa Cruz Biotechnology
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ZFYVE28 shRNA Plasmid (h) - sc-89030-SH from Santa Cruz Biotechnology
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ZFYVE28 shRNA (h) Lentiviral Particles - sc-89030-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23209 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23209 from Sigma-Aldrich
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ZFYVE28 siRNA (Human) - CRJ1668 from Cohesion Biosciences
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ZFYVE28 RNAi - H00057732-R01 from Novus Biologicals
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ZFYVE28 - MBS8230043 from MyBioSource
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shRNA set against Human ZFYVE28 (NM_020972.2) - SHH452528 from Creative biogene
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ZFYVE28 shRNA Plasmid (Human) - CHJ1668 from Cohesion Biosciences
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