PCDH15
| Gene Symbol | PCDH15 |
|---|---|
| Entrez Gene | 65217 |
| Alt Symbol | CDHR15, DFNB23, USH1F |
| Species | Human |
| Gene Type | protein-coding |
| Description | protocadherin-related 15 |
| Other Description | cadherin-related family member 15|protocadherin-15 |
| Swissprots | C6ZEF6 Q5VY38 Q96QU1 Q6TRH8 Q8NDB9 C6ZEF7 Q5VY39 A6NL19 Q96QT8 C6ZEF5 |
| Accessions | EAW54151 EAW54152 Q96QU1 AK126923 BAG54399 AL834134 CAD38850 AW005431 AY029205 AAK31581 AY029237 AAK31804 AY388963 AAR26468 BC156450 AAI56451 EU718480 ACF76476 EU718481 ACF76477 EU718482 ACF76478 NM_001142763 NP_001136235 NM_001142764 NP_001136236 NM_001142765 NP_001136237 NM_001142766 NP_001136238 NM_001142767 NP_001136239 NM_001142768 NP_001136240 NM_001142769 NP_001136241 NM_001142770 NP_001136242 NM_001142771 NP_001136243 NM_001142772 NP_001136244 NM_001142773 NP_001136245 NM_033056 NP_149045 |
| Function | Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Efficient localization to the plasma membrane requires the presence of LHFPL5. {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed. {ECO:0000269|PubMed:11487575, ECO:0000269|PubMed:16369489, ECO:0000269|PubMed:18719945}. |
PCDH15 CRISPR/Cas9 KO Plasmid (h) - sc-404591 from Santa Cruz Biotechnology
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PCDH15 HDR Plasmid (h) - sc-404591-HDR from Santa Cruz Biotechnology
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PCDH15 Double Nickase Plasmid (h) - sc-404591-NIC from Santa Cruz Biotechnology
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PCDH15 Double Nickase Plasmid (h2) - sc-404591-NIC-2 from Santa Cruz Biotechnology
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PCDH15 CRISPR Activation Plasmid (h) - sc-404591-ACT from Santa Cruz Biotechnology
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PCDH15 CRISPR Activation Plasmid (h2) - sc-404591-ACT-2 from Santa Cruz Biotechnology
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PCDH15 Lentiviral Activation Particles (h) - sc-404591-LAC from Santa Cruz Biotechnology
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PCDH15 Lentiviral Activation Particles (h2) - sc-404591-LAC-2 from Santa Cruz Biotechnology
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PCDH15 siRNA (h) - sc-90494 from Santa Cruz Biotechnology
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PCDH15 shRNA Plasmid (h) - sc-90494-SH from Santa Cruz Biotechnology
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PCDH15 shRNA (h) Lentiviral Particles - sc-90494-V from Santa Cruz Biotechnology
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Protocadherin-15 RNAi - H00065217-R01 from Novus Biologicals
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MISSION® esiRNA - EHU079621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16403 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16403 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06460 from Sigma-Aldrich
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PCDH15 siRNA (Human) - CRJ2190 from Cohesion Biosciences
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shRNA set against Human PCDH15 (NM_033056.3) - SHH371464 from Creative biogene
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PCDH15 shRNA Plasmid (Human) - CHJ2190 from Cohesion Biosciences
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PCDH15 miRNA 3'UTR clone - MiUTR1H-07565 from Creative biogene
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PCDH15 miRNA 3'UTR clone - MiUTR3H-07747 from Creative biogene
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PCDH15 miRNA 3'UTR clone - MiUTR3H-07748 from Creative biogene
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PCDH15 miRNA 3'UTR clone - MiUTR3H-07749 from Creative biogene
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PCDH15 miRNA 3'UTR clone - MiUTR3H-07750 from Creative biogene
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PCDH15 miRNA 3'UTR clone - MiUTR3H-07751 from Creative biogene
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