PCDH15

Gene Symbol PCDH15
Entrez Gene 65217
Alt Symbol CDHR15, DFNB23, USH1F
Species Human
Gene Type protein-coding
Description protocadherin-related 15
Other Description cadherin-related family member 15|protocadherin-15
Swissprots C6ZEF6 Q5VY38 Q96QU1 Q6TRH8 Q8NDB9 C6ZEF7 Q5VY39 A6NL19 Q96QT8 C6ZEF5
Accessions EAW54151 EAW54152 Q96QU1 AK126923 BAG54399 AL834134 CAD38850 AW005431 AY029205 AAK31581 AY029237 AAK31804 AY388963 AAR26468 BC156450 AAI56451 EU718480 ACF76476 EU718481 ACF76477 EU718482 ACF76478 NM_001142763 NP_001136235 NM_001142764 NP_001136236 NM_001142765 NP_001136237 NM_001142766 NP_001136238 NM_001142767 NP_001136239 NM_001142768 NP_001136240 NM_001142769 NP_001136241 NM_001142770 NP_001136242 NM_001142771 NP_001136243 NM_001142772 NP_001136244 NM_001142773 NP_001136245 NM_033056 NP_149045
Function Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Efficient localization to the plasma membrane requires the presence of LHFPL5. {ECO:0000250}.
Tissue Specificity Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed. {ECO:0000269|PubMed:11487575, ECO:0000269|PubMed:16369489, ECO:0000269|PubMed:18719945}.

PCDH15 (H-3) - sc-377235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PCDH15 (H-3): sc-377235. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear membrane localization.

PCDH15 (H-300) - sc-98647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PCDH15 (N-13) - sc-107052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PCDH15 (N-13): sc-107052. Western blot analysis of PCDH15 expression in HeLa (A), Jurkat (B), NTERA-2 cl.D1 (C) and K-562 (D) whole cell lysates.

PCDH15 (D-21) - sc-133891 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
PCDH15 (D-21): sc-133891. Western blot analysis of PCDH15 expression in Hep G2 whole cell lysate.

Anti-PCDH15 Antibody (aa27-376) - LS-C182938 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PCDH15 Antibody (aa112-161) - LS-C81525 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6%-18%.

Protocadherin-15 Antibody - AF6729 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Western Blot Protocadherin-15 Antibody

Protocadherin-15 Antibody (740523) - MAB6729 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 740523
Protocadherin‑15 was detected in immersion fixed YT human leukemia natural killer‑like cell line using Mouse Anti-Human Protocadherin‑15 Monoclonal Antibody (Catalog # MAB6729) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Protocadherin-15 Antibody - NBP1-60065 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Protocadherin-15 Antibody [NBP1-60065] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

Protocadherin-15 Antibody - 20950002 from Novus Biologicals

Prices $429.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Protocadherin-15 Antibody - 46010002 from Novus Biologicals

Prices $429.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: Protocadherin-15 Antibody [46010002]

Anti-PCDH15 antibody produced in rabbit - AV50153 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV50153</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HepG2

PCDH15 antibody - N-terminal region (ARP50153_P050) - ARP50153_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PCDH15 antibody, N-term - GTX45912 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

Human Protocadherin-15 Antibody - AF6729 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of Human Protocadherin-15 by Western Blot. Western blot shows lysates of HEK293T human embryonic kidney cell line and HEK293T cell line spiked with Recombinant Human Protocadherin-15 (5 ng/lane). PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human Protocadherin-15 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6729) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for Protocadherin-15 at approximately 190 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8 .
Detection of Human Protocadherin-15 by Western Blot. Western blot shows lysates of HEK293T human embryonic kidney cell line and HEK293T cell line spiked with Recombinant Human Protocadherin-15 (5 ng/lane). PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human Protocadherin-15 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6729) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Protocadherin-15 at approximately 190 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Human Protocadherin-15 Antibody - MAB6729 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clone 740523
Protocadherin-15 in YT Human Cell Line. Protocadherin-15 was detected in immersion fixed YT human leukemia natural killer-like cell line using Mouse Anti-Human Protocadherin-15 Monoclonal Antibody (Catalog # MAB6729) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007 ) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells .

Human Protocadherin-15 MAb (Clone 740523), Mouse IgG2B - MAB6729-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 740523
Protocadherin‑15 in YT Human Cell Line. Protocadherin‑15 was detected in immersion fixed YT human leukemia natural killer‑like cell line using Mouse Anti-Human Protocadherin‑15 Monoclonal Antibody (Catalog # MAB6729) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

PCDH15 antibody - 70R-6995 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PCDH15 Antibody - 30-579 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Human HepG2 at 0.2-1 ug/ml.

PCDH15 Antibody - GWB-MR803B from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Protocadherin 15 (PCDH15) - MAE095Hu21 from Uscn Life Science Inc.

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Protocadherin 15 (PCDH15) - PAE095Hu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Protocadherin 15 (PCDH15) - PAE095Mu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Protocadherin 15 (PCDH15) - PAE095Mu02 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal
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