| Gene Symbol |
Chst2
|
| Entrez Gene |
54371
|
| Alt Symbol |
AI428561, AW121776, C130041E03Rik, Chts2, GST-2, GlcNAc6ST, Gn6st
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate sulfotransferase 2
|
| Other Description |
N-acetylglucosamine 6-O-sulfotransferase 1|N-acetylglucosamine-6-O-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2|glcNAc6ST-1|gn6st-1
|
| Swissprots |
Q794G9 O88276 Q80WV3 E9QNG2
|
| Accessions |
BAD16775 CAL85379 EDL20935 Q80WV3 AB011451 BAA32137 AB011452 BAA32138 AK034634 AK048226 AK131820 BAE20819 AW121776 BC051963 AAH51963 BM947059 BM950407 BU701895 CJ172365 NM_018763 NP_061233
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:15175329, ECO:0000269|PubMed:9712885}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
In brain, it is expressed in pyramidal cells in the CA3 subregion of the hippocampus, cerebellar nucleus and Purkinje cells. {ECO:0000269|PubMed:9712885, ECO:0000269|PubMed:9722682}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - keratan sulfate
|