| Gene Symbol | Chst2 |
|---|---|
| Entrez Gene | 54371 |
| Alt Symbol | AI428561, AW121776, C130041E03Rik, Chts2, GST-2, GlcNAc6ST, Gn6st |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate sulfotransferase 2 |
| Other Description | N-acetylglucosamine 6-O-sulfotransferase 1|N-acetylglucosamine-6-O-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2|glcNAc6ST-1|gn6st-1 |
| Swissprots | Q794G9 O88276 Q80WV3 E9QNG2 |
| Accessions | BAD16775 CAL85379 EDL20935 Q80WV3 AB011451 BAA32137 AB011452 BAA32138 AK034634 AK048226 AK131820 BAE20819 AW121776 BC051963 AAH51963 BM947059 BM950407 BU701895 CJ172365 NM_018763 NP_061233 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:15175329, ECO:0000269|PubMed:9712885}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | In brain, it is expressed in pyramidal cells in the CA3 subregion of the hippocampus, cerebellar nucleus and Purkinje cells. {ECO:0000269|PubMed:9712885, ECO:0000269|PubMed:9722682}. |
| Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |