| Gene Symbol |
GATA4
|
| Entrez Gene |
2626
|
| Alt Symbol |
ASD2, TACHD, TOF, VSD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GATA binding protein 4
|
| Other Description |
GATA-binding factor 4|transcription factor GATA-4
|
| Swissprots |
Q5IFM8 P43694 Q3MJ45 B7ZKZ4 B7ZKX0
|
| Accessions |
AAA70335 ABY49125 ABY84859 ABY84860 ABY84861 ABY84862 ABY84863 ABY84864 ABY84865 ACD13586 ACD13587 EAW65620 EAW65621 P43694 AF180736 AF318320 AAL55827 AI192760 AK097060 BAG53416 AY740706 AAW51922 BC033672 BC068079 BC101580 AAI01581 BC105108 AAI05109 BC143434 AAI43435 BC143479 AAI43480 BM560562 BM768332 BQ439274 D78260 BAA11334 DA900813 DR003768 FJ169610 ACI04537 HY015197 HY023604 L34357 AAA58496 XM_005272384 XP_005272441 XM_005272385 XP_005272442 XM_005272386 XP_005272443 XM_006716248 XP_006716311 XM_006716249 XP_006716312 XM_011543817 XP_011542119 XM_011543818 XP_011542120 NM_001308093 NP_001295022 NM_001308094 NP_001295023 NM_002052 NP_002043
|
| Function |
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. {ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169}.
|
| Top Pathways |
cGMP-PKG signaling pathway
|
![Western Blot: GATA4 Overexpression Lysate (Adult Normal) [NBL1-10983] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GATA4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4246_GATA4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10983-img0002.jpg)