| Gene Symbol |
HHIP
|
| Entrez Gene |
64399
|
| Alt Symbol |
HIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hedgehog interacting protein
|
| Other Description |
hedgehog-interacting protein
|
| Swissprots |
Q9H7E7 Q6PK09 Q9BXK3 Q8NCI7 Q9H1J4 Q96QV1
|
| Accessions |
AAK18182 CAK96038 CBI67672 EAX05054 Q96QV1 AK024645 BAB14945 AK074711 BAC11154 AK098525 AK291849 BAF84538 AY009317 AAG35411 AY009951 AAG34731 AY358747 AAQ89107 BC009298 AAH09298 BC015636 BC025311 AAH25311 BI602235 DQ893618 ABM84544 XM_005263178 XP_005263235 XM_006714288 XP_006714351 NM_022475 NP_071920
|
| Function |
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:19561609}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.
|
| Tissue Specificity |
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269|PubMed:11435703, ECO:0000269|Ref.1}.
|
| Top Pathways |
Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway
|