Gene Symbol | HHIP |
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Entrez Gene | 64399 |
Alt Symbol | HIP |
Species | Human |
Gene Type | protein-coding |
Description | hedgehog interacting protein |
Other Description | hedgehog-interacting protein |
Swissprots | Q9H7E7 Q6PK09 Q9BXK3 Q8NCI7 Q9H1J4 Q96QV1 |
Accessions | AAK18182 CAK96038 CBI67672 EAX05054 Q96QV1 AK024645 BAB14945 AK074711 BAC11154 AK098525 AK291849 BAF84538 AY009317 AAG35411 AY009951 AAG34731 AY358747 AAQ89107 BC009298 AAH09298 BC015636 BC025311 AAH25311 BI602235 DQ893618 ABM84544 XM_005263178 XP_005263235 XM_006714288 XP_006714351 NM_022475 NP_071920 |
Function | Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:19561609}. |
Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment. |
Tissue Specificity | Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269|PubMed:11435703, ECO:0000269|Ref.1}. |
Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway |
Hhip CRISPR/Cas9 KO Plasmid (h) - sc-403293 from Santa Cruz Biotechnology
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Hhip HDR Plasmid (h) - sc-403293-HDR from Santa Cruz Biotechnology
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Hhip Double Nickase Plasmid (h) - sc-403293-NIC from Santa Cruz Biotechnology
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Hhip Double Nickase Plasmid (h2) - sc-403293-NIC-2 from Santa Cruz Biotechnology
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Hhip CRISPR Activation Plasmid (h) - sc-403293-ACT from Santa Cruz Biotechnology
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Hhip CRISPR Activation Plasmid (h2) - sc-403293-ACT-2 from Santa Cruz Biotechnology
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Hhip Lentiviral Activation Particles (h) - sc-403293-LAC from Santa Cruz Biotechnology
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Hhip Lentiviral Activation Particles (h2) - sc-403293-LAC-2 from Santa Cruz Biotechnology
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Hhip siRNA (h) - sc-43835 from Santa Cruz Biotechnology
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Hhip shRNA Plasmid (h) - sc-43835-SH from Santa Cruz Biotechnology
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Hhip shRNA (h) Lentiviral Particles - sc-43835-V from Santa Cruz Biotechnology
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Hip RNAi - H00064399-R01 from Novus Biologicals
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MISSION® esiRNA - EHU040921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10018 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10018 from Sigma-Aldrich
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HHIP siRNA (Human) - CRJ2004 from Cohesion Biosciences
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HHIP - MBS827055 from MyBioSource
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shRNA set against Human HHIP (NM_022475.2) - SHH311989 from Creative biogene
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Human HHIP siRNA - orb272505 from Biorbyt
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HHIP shRNA Plasmid (Human) - CHJ2004 from Cohesion Biosciences
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HHIP miRNA 3'UTR clone - MiUTR3H-08272 from Creative biogene
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