OCA2

Gene Symbol OCA2
Entrez Gene 4948
Alt Symbol BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1
Species Human
Gene Type protein-coding
Description oculocutaneous albinism II
Other Description P protein|P-protein|eye color 2 (central brown)|eye color 3 (brown)|hair color 3 (brown)|melanocyte-specific transporter protein|oculocutaneous albinism II (pink-eye dilution homolog, mouse)|pink-eyed dilution protein homolog|total brown iris pigmentation
Swissprots Q96EN1 Q9UMI5 Q15212 Q15211 Q04671
Accessions AAC13783 AAC13784 EAW57661 EAW57662 EAW57663 Q04671 BC012097 AAH12097 BX398277 M97901 AAA36430 M99564 AAA36477 XM_011521639 XP_011519941 XM_011521640 XP_011519942 XM_011521641 XP_011519943 XM_011521642 XP_011519944 XM_011521643 XP_011519945 XM_011521644 XP_011519946 XM_011521645 XP_011519947 XM_011521646 XP_011519948 XM_011521647 XP_011519949 XR_931843 NM_000275 NP_000266 NM_001300984 NP_001287913
Function Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. {ECO:0000269|PubMed:11310796, ECO:0000269|PubMed:15262401, ECO:0000269|PubMed:18252222, ECO:0000269|PubMed:22234890, ECO:0000269|PubMed:7601462}.
Subcellular Location Melanosome membrane {ECO:0000269|PubMed:7601462}; Multi-pass membrane protein {ECO:0000269|PubMed:7601462}.

Anti-P protein antibody - ab196500 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P protein antibody (ab196500) at 1/500 dilutionLane 1 : 293T cell lysateLane 2 : SGC-7901 cell lysateLane 3 : U937 cell lysateLane 4 : BT474 cell lysateLane 5 : Mouse testis tissue lysateLane 6 : Mouse craniofacial tissue lysateLane 7 : Mouse eye tissue lysate

Anti-P protein antibody - ab106990 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-P protein antibody (ab106990) at 1/100 dilution + 293 cell line lysates at 35 µg

Anti-OCA2 / P protein Antibody (aa111-138) - LS-C163100 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
OCA2 Antibody western blot of 293 cell line lysates (35 ug/lane). The OCA2 antibody detected the OCA2 protein (arrow).

Anti-OCA2 / P protein Antibody - LS-C334201 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using OCA2 antibody.

Anti-OCA2 / P protein Antibody (aa468-517) IHC-plus™ - LS-B5779 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-OCA2 / P Protein antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5779 concentration 5 ug/ml.

Anti-OCA2 / P protein Antibody (clone 1A11) - LS-C197813 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11

Anti-OCA2 / P protein Antibody (aa118-146, APC) - LS-C264926 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa118-146, AP) - LS-C264927 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa118-146, PE) - LS-C264931 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa118-146, FITC) - LS-C264928 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa118-146, Biotin) - LS-C264929 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa118-146, Azide-free, HRP) - LS-C264930 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa118-146) - LS-C323509 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody - LS-C341683 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OCA2 / P protein Antibody (aa430-479) - LS-C201472 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human OVCAR-3. OCA2 antibody dilution 1.0 ug/ml.

OCA2 Antibody - NBP1-60052 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OCA2 Antibody [NBP1-60052] - Human Placenta lysate, concentration 0.2-1 ug/ml.

OCA2 Antibody - NBP1-88649 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OCA2 Antibody [NBP1-88649] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)<br/>Lane 5: Human liver tissue<br/>Lane 6: Human tonsil tissue

OCA2 Antibody (1A11) - H00004948-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11

Anti-OCA2 antibody produced in rabbit - HPA036403 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OCA2: <B>Cat. No. HPA036403</B>: Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

Monoclonal Anti-OCA2 antibody produced in mouse - SAB1401270 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11

Anti-OCA2 antibody produced in rabbit - SAB2101673 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-OCA2: <B>Cat. No.SAB2101673</B>: OCA2 in Placenta tissue lysate with OCA2 antibody at 1.0 μg/mL.

OCA2 Antibody - C-terminal region (ARP44254_P050) - ARP44254_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OCA2 antibody - middle region (ARP44255_P050) - ARP44255_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OCA2 Antibody - N-terminal region (OAAB00205) - OAAB00205 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

OCA2-Antibody-N-Term - AP10199a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
OCA2 Antibody (N-Term) (Cat. #AP10199a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the OCA2 antibody detected the OCA2 protein (arrow).
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