OCA2

Gene Symbol OCA2
Entrez Gene 4948
Alt Symbol BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1
Species Human
Gene Type protein-coding
Description oculocutaneous albinism II
Other Description P protein|P-protein|eye color 2 (central brown)|eye color 3 (brown)|hair color 3 (brown)|melanocyte-specific transporter protein|oculocutaneous albinism II (pink-eye dilution homolog, mouse)|pink-eyed dilution protein homolog|total brown iris pigmentation
Swissprots Q96EN1 Q9UMI5 Q15212 Q15211 Q04671
Accessions AAC13783 AAC13784 EAW57661 EAW57662 EAW57663 Q04671 BC012097 AAH12097 BX398277 M97901 AAA36430 M99564 AAA36477 XM_011521639 XP_011519941 XM_011521640 XP_011519942 XM_011521641 XP_011519943 XM_011521642 XP_011519944 XM_011521643 XP_011519945 XM_011521644 XP_011519946 XM_011521645 XP_011519947 XM_011521646 XP_011519948 XM_011521647 XP_011519949 XR_931843 NM_000275 NP_000266 NM_001300984 NP_001287913
Function Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. {ECO:0000269|PubMed:11310796, ECO:0000269|PubMed:15262401, ECO:0000269|PubMed:18252222, ECO:0000269|PubMed:22234890, ECO:0000269|PubMed:7601462}.
Subcellular Location Melanosome membrane {ECO:0000269|PubMed:7601462}; Multi-pass membrane protein {ECO:0000269|PubMed:7601462}.

Human P protein protein fragment - ab116803 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE showing ab116803 at approximately 36.63kDa. Stained with Coomassie Blue.

OCA2 / P protein Antibody Blocking Peptide - LS-E106 from LifeSpan Bioscience

Category Protein
Prices $145.00
Sizes 100 µg

OCA2 / P protein Antibody Blocking Peptide - LS-E16255 from LifeSpan Bioscience

Category Protein
Prices $145.00
Sizes 100 µg

Recombinant Human OCA2 Protein - H00004948-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

OCA2-Antibody-N-Term-Blocking-peptide - BP10199a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

OCA2 Blocking Peptide - 33R-5036 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

P protein - H00004948-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

P protein - H00004948-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

OCA2 fusion protein - ag1867 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human OCA2 - OCA2-30532TH from Creative Biomart

Category Protein
Source Wheat germ
Species Human

OCA2 fusion protein - Ag24841 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

OCA2 Peptide, Human - M34GP10796H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

OCA2 fusion protein - Ag24864 from Proteintech Group

Category Protein
Source E. coli -derived, PGEX-4T
Species Human
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