Tgfbr1

Gene Symbol Tgfbr1
Entrez Gene 21812
Alt Symbol ALK5, AU017191, Alk-5, TbetaR-I, TbetaRI
Species Mouse
Gene Type protein-coding
Description transforming growth factor, beta receptor I
Other Description ESK2|TGF-beta receptor type I|TGF-beta receptor type-1|TGFR-1|transforming growth factor-beta receptor type I
Swissprots Q64729 A2AJN0
Accessions CAT04599 EDL02353 Q64729 AK007125 BAB24865 AK015337 BAB29802 AK153796 AK154381 BAE32548 BC063260 AAH63260 CT010393 CAJ18600 D25540 BAA05023 D28526 BAA05878 XM_006537756 XP_006537819 XM_006537757 XP_006537820 NM_009370 NP_033396
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

TGFβ RI (RM0016-3A11) - sc-101574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rat
Clonality Monoclonal

TGF-beta RI/ALK-5 Antibody - AF587 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

TGF-beta RI/ALK-5 Antibody (RM0016-3A11) - NBP2-11921 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM0016-3A11
Immunohistochemistry-Paraffin: TGF-beta RI/ALK-5 Antibody (RM0016-3A11) [NBP2-11921] - Parrafin lung and kidney sections from LPS treated mice using anti ALK5 antibody.

TGF-beta RI/ALK-5 Antibody [Biotin] - BAF587 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

TGF-beta RI/ALK-5 Antibody (141231) [PE] - FAB5871P-025 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 141231

TGF-beta RI/ALK-5 Antibody (141231) [Allophycocyanin] - FAB5871A-025 from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 141231

ANTI-MOUSE TGFBR1 (CENTER) antibody produced in rabbit - SAB1302521 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-Mouse Tgfbr1 (Center): <B>Cat. No. SAB1302521</B>: Mouse Tgfbr1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35 μg/lane).

Mouse-Tgfbr1-Antibody-Center - AP14778c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Tgfbr1 Antibody (Center) (Cat. #AP14778c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Tgfbr1 antibody detected the Tgfbr1 protein (arrow).

Mouse Tgfbr1 Antibody - middle region (OAAB11109) - OAAB11109 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Mouse Tgfbr1 Antibody - abx028298 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-TGFBR1 antibody - STJ72633 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

ALK-5, Monoclonal Antibody - MBS690892 from MyBioSource

Prices $460.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 3A11

ALK5 antibody - 70R-50476 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Tgfbr1, Polyclonal Antibody - MBS9207501 from MyBioSource

Prices $155.00, $340.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal

Tgfbr1 Antibody (F44154) - F44154 from NSJ Bioreagent

Prices $125.00, $299.00
Sizes 80 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide), 400 µl (In 1X PBS, pH 7.4, with 0.09% sodium azide)
Host Rabbit
Clonality Polyclonal
Tgfbr1 antibody western blot analysis in mouse kidney tissue lysate. Predicted molecular weight: ~55kDa.

Mouse Tgfbr1 Antibody - 57-980 from ProSci

Prices $375.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis in mouse kidney tissue lysates (35ug/lane).
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