Tgfbr1

Gene Symbol Tgfbr1
Entrez Gene 21812
Alt Symbol ALK5, AU017191, Alk-5, TbetaR-I, TbetaRI
Species Mouse
Gene Type protein-coding
Description transforming growth factor, beta receptor I
Other Description ESK2|TGF-beta receptor type I|TGF-beta receptor type-1|TGFR-1|transforming growth factor-beta receptor type I
Swissprots Q64729 A2AJN0
Accessions CAT04599 EDL02353 Q64729 AK007125 BAB24865 AK015337 BAB29802 AK153796 AK154381 BAE32548 BC063260 AAH63260 CT010393 CAJ18600 D25540 BAA05023 D28526 BAA05878 XM_006537756 XP_006537819 XM_006537757 XP_006537820 NM_009370 NP_033396
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera, CF - 587-RI-050 from R&D Systems

Category Protein
Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Mouse Transforming Growth Factor, Beta Receptor I - Tgfbr1-1777M from Creative Biomart

Category Protein
Source Sf21 Insect Cells .

Recombinant Mouse Tgfbr1, Fc Chimera - Tgfbr1-439M from Creative Biomart

Category Protein
Source Baculovirus Sf 21 Insect cells
Species Mouse

Recombinant Mouse TGF-beta receptor type-1(Tgfbr1) - CSB-YP734134MO CSB-EP734134MO CSB-BP734134MO CSB-MP734134MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse TGF-beta RI/ALK-5 Fc Chimera Protein, CF - 587-RI from R&D Systems

Category Protein
Prices $349.00
Sizes 50 µg
Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Mouse TGF-beta RI (Ala21-Glu121) & (Thr22-Glu121) Accession # BAA05023 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus
Species Mouse

TGF-beta receptor type-1 (Tgfbr1), Recombinant Protein - MBS1405977 from MyBioSource

Category Protein
Prices $830.00, $830.00, $1,055.00, $1,055.00, $1,185.00, $1,185.00, $1,640.00, $1,640.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

TGFBR1, Recombinant Protein - MBS515694 from MyBioSource

Category Protein
Prices $290.00, $375.00
Sizes 5 µg, 10 µg
Source Sf9 insect cells using baculovirus
Species Mouse
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