Tgfbr1

Gene Symbol Tgfbr1
Entrez Gene 21812
Alt Symbol ALK5, AU017191, Alk-5, TbetaR-I, TbetaRI
Species Mouse
Gene Type protein-coding
Description transforming growth factor, beta receptor I
Other Description ESK2|TGF-beta receptor type I|TGF-beta receptor type-1|TGFR-1|transforming growth factor-beta receptor type I
Swissprots Q64729 A2AJN0
Accessions CAT04599 EDL02353 Q64729 AK007125 BAB24865 AK015337 BAB29802 AK153796 AK154381 BAE32548 BC063260 AAH63260 CT010393 CAJ18600 D25540 BAA05023 D28526 BAA05878 XM_006537756 XP_006537819 XM_006537757 XP_006537820 NM_009370 NP_033396
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

TGF-beta receptor type-1, Tgfbr1, Mouse, ELISA Kit - E8813m from ARP American Research Products

Category ELISA Kit
Prices $736.00
Sizes 96 t

Mouse TGF-beta receptor type-1(TGFBR1) ELISA kit - CSB-EL023451MO from Cusabio

Category ELISA Kit
Sensitivity 1.95 pg/ml
Range 7.8 pg/ml-500 pg/ml

transforming growth factor, beta receptor 1, ELISA Kit - MBS904958 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse TGFbR1 ELISA Kit - abx154747 from Abbexa

Category ELISA Kit
Sensitivity 0.069 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Mouse TGFbR1 ELISA Kit - abx571716 from Abbexa

Category ELISA Kit
Sensitivity 0.069 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Mouse TGF-beta receptor type-1 (TGFBR1) ELISA Kit - EKC37906 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 1.95 pg/ml
Range 7.8 pg/ml-500 pg/ml

Mouse Tgfbr1 ELISA Kit - E069891 from Biobool

Category ELISA Kit

TGFBR1 ELISA Kit (Mouse) (OKCD02924) - OKCD02924 from Aviva Systems Biology

Category ELISA Kit
Prices $515.00
Sizes 10 ng
Sensitivity 0.061 ng/mL
Range 0.156-10 ng/mL

TGF-beta receptor type-1, ELISA Kit - MBS2884046 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I (TGFbR1), ELISA Kit - MBS453529 from MyBioSource

Category ELISA Kit
Prices $355.00, $465.00, $1,995.00, $3,870.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.069ng/mL
Range 0.156-10ng/mL
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