TERT
| Gene Symbol | TERT |
|---|---|
| Entrez Gene | 7015 |
| Alt Symbol | CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT |
| Species | Human |
| Gene Type | protein-coding |
| Description | telomerase reverse transcriptase |
| Other Description | telomerase catalytic subunit|telomerase-associated protein 2 |
| Swissprots | O14746 Q8NG38 Q2XS35 Q8N6C3 Q8NG46 O14783 |
| Accessions | AAD12057 AAD12786 AAD17210 AAD24464 AAD30037 AAG23289 ABB72674 BAA74724 BAA78344 CAM33584 CAM91189 CBW46529 EAX08165 EAX08166 EAX08167 EAX08168 EAX08169 EAX08170 EAX08171 O14746 AB085628 BAC11010 AB086379 BAC11014 AB086950 BAC11015 AF015950 AAC51672 AF018167 AAC51724 AF043739 AAC40212 AX810036 CAE75638 AX810378 CAE75644 BC062321 BC156388 AAI56389 BC172541 AAI72541 JF896280 JF896281 JF896282 AEF12311 JF896283 JF896284 JF896285 AEF12312 JF896286 XM_011514104 XP_011512406 XM_011514105 XP_011512407 XM_011514106 XP_011512408 NM_001193376 NP_001180305 NM_198253 NP_937983 NM_198254 NM_198255 |
| Function | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifi |
| Subcellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress- mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT. |
| Tissue Specificity | Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T- lymphocytes. {ECO:0000269|PubMed:8676067, ECO:0000269|PubMed:9389643}. |
| Top Pathways | HTLV-I infection |
Human TERT / Telomerase ELISA Kit (Cell-Based ELISA) - LS-F2346 from LifeSpan Bioscience
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Human Phospho-TERT / Telomerase (Ser824) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1428 from LifeSpan Bioscience
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Human TERT / Telomerase ELISA Kit (Sandwich ELISA) - LS-F7351 from LifeSpan Bioscience
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Rat TERT / Telomerase ELISA Kit (Sandwich ELISA) - LS-F9171 from LifeSpan Bioscience
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Dog TERT / Telomerase ELISA Kit (Sandwich ELISA) - LS-F12715 from LifeSpan Bioscience
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Bovine TERT / Telomerase ELISA Kit (Sandwich ELISA) - LS-F12714 from LifeSpan Bioscience
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Human TERT / Telomerase ELISA Kit (Sandwich ELISA) - LS-F12713 from LifeSpan Bioscience
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Mouse TERT / Telomerase ELISA Kit (Sandwich ELISA) - LS-F12716 from LifeSpan Bioscience
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Telomerase reverse transcriptase (TERT), Human, ELISA Kit - CSB-EL023391HU from ARP American Research Products
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Telomerase Reverse Transcriptase (TERT), Human, ELISA Kit - SEC241Hu from ARP American Research Products
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Telomerase Reverse Transcriptase, Human, ELISA Kit - E01T0601 from ARP American Research Products
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Telomerase reverse transcriptase, TERT, Human, ELISA Kit - E2133h from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Human, ELISA Kit - E-EL-H0706 from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Rabbit, ELISA Kit - E-EL-RB1273 from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Chicken, ELISA Kit - E-EL-Ch1374 from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Porcine, ELISA Kit - E-EL-P0754 from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Sheep, ELISA Kit - E-EL-S0895 from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Guinea Pig, ELISA Kit - E-EL-GP1107 from ARP American Research Products
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Telomerase Reverse Transcriptase, TERT, Monkey, ELISA Kit - E-EL-MK2073 from ARP American Research Products
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Telomerase Colorimetric Cell-Based ELISA Kit - CB5678 from Assay Biotechnology
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Telomerase (Phospho-Ser824) Colorimetric Cell-Based ELISA Kit - CBP1460 from Assay Biotechnology
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Human Telomerase Reverse Transcriptase (hTERT) ELISA Kit - DEIA8150 from Creative Diagnostics
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Human TERT(Telomerase Reverse Transcriptase) ELISA Kit - E-EL-H0706 from Elabscience
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Human TERT (Telomerase Reverse Transcriptase) CLIA Kit - E-CL-H0517 from Elabscience
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Telomerase, ELISA Kit - MBS013572 from MyBioSource
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