TERT

Gene Symbol	TERT
Entrez Gene	7015
Alt Symbol	CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
Species	Human
Gene Type	protein-coding
Description	telomerase reverse transcriptase
Other Description	telomerase catalytic subunit|telomerase-associated protein 2
Swissprots	O14746 Q8NG38 Q2XS35 Q8N6C3 Q8NG46 O14783
Accessions	AAD12057 AAD12786 AAD17210 AAD24464 AAD30037 AAG23289 ABB72674 BAA74724 BAA78344 CAM33584 CAM91189 CBW46529 EAX08165 EAX08166 EAX08167 EAX08168 EAX08169 EAX08170 EAX08171 O14746 AB085628 BAC11010 AB086379 BAC11014 AB086950 BAC11015 AF015950 AAC51672 AF018167 AAC51724 AF043739 AAC40212 AX810036 CAE75638 AX810378 CAE75644 BC062321 BC156388 AAI56389 BC172541 AAI72541 JF896280 JF896281 JF896282 AEF12311 JF896283 JF896284 JF896285 AEF12312 JF896286 XM_011514104 XP_011512406 XM_011514105 XP_011512407 XM_011514106 XP_011512408 NM_001193376 NP_001180305 NM_198253 NP_937983 NM_198254 NM_198255
Function	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifi
Subcellular Location	Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress- mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.
Tissue Specificity	Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T- lymphocytes. {ECO:0000269|PubMed:8676067, ECO:0000269|PubMed:9389643}.
Top Pathways	HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Telomerase reverse transcriptase peptide - ab24029 from Abcam Category Peptide Species Human

Human Telomerase reverse transcriptase peptide - ab105632 from Abcam Category Peptide

Human Telomerase reverse transcriptase peptide - ab19040 from Abcam Category Peptide Species Human

TERT / Telomerase Blocking Peptide - LS-E2980 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERT / Telomerase Antibody Blocking Peptide - LS-E2979 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERT / Telomerase Antibody Blocking Peptide - LS-E27822 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERT / Telomerase Antibody Blocking Peptide - LS-E7414 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERT / Telomerase Antibody Blocking Peptide - LS-E7443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERT Peptide - P0373 from Novus Biologicals Category Peptide Species Human

TERT Peptide - P1674 from Novus Biologicals Category Peptide Species Human

TERT-Y707-Antibody-Blocking-Peptide - BP1410e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TERT-Antibody-S1125-Blocking-Peptide - BP1410d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TERT-Antibody-Center-Blocking-Peptide - BP1410c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-TERTY707-Antibody-Blocking-peptide - BP3619a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-TERTS1125-Antibody-Blocking-peptide - BP3544a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Recombinant human Telomerase reverse transcriptase (OPCA00884) - OPCA00884 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human TERT protein - orb245474 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

TERT Immunizing peptide - orb66298 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human TERT Protein - abx069251 from Abbexa Category Protein Source E.coli Species Human

Telomerase Reverse Transcriptase Peptide - AC21-2632-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Telomerase Reverse Transcriptase (TERT), Human - 20-8420 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

TERT Peptide - 42-961P from ProSci Category Peptide Species Human

Human Telomerase reverse transcriptase peptide - TERT-561H from Creative Biomart Category Peptide Species Human

Recombinant Human Tert - Tert-550H from Creative Biomart Category Protein Source E. coli

Recombinant Mouse Telomerase Reverse Transcriptase - Tert-574M from Creative Biomart Category Protein Source E. coli.

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