| Gene Symbol |
TERT
|
| Entrez Gene |
7015
|
| Alt Symbol |
CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
telomerase reverse transcriptase
|
| Other Description |
telomerase catalytic subunit|telomerase-associated protein 2
|
| Swissprots |
O14746 Q8NG38 Q2XS35 Q8N6C3 Q8NG46 O14783
|
| Accessions |
AAD12057 AAD12786 AAD17210 AAD24464 AAD30037 AAG23289 ABB72674 BAA74724 BAA78344 CAM33584 CAM91189 CBW46529 EAX08165 EAX08166 EAX08167 EAX08168 EAX08169 EAX08170 EAX08171 O14746 AB085628 BAC11010 AB086379 BAC11014 AB086950 BAC11015 AF015950 AAC51672 AF018167 AAC51724 AF043739 AAC40212 AX810036 CAE75638 AX810378 CAE75644 BC062321 BC156388 AAI56389 BC172541 AAI72541 JF896280 JF896281 JF896282 AEF12311 JF896283 JF896284 JF896285 AEF12312 JF896286 XM_011514104 XP_011512406 XM_011514105 XP_011512407 XM_011514106 XP_011512408 NM_001193376 NP_001180305 NM_198253 NP_937983 NM_198254 NM_198255
|
| Function |
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifi
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress- mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.
|
| Tissue Specificity |
Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T- lymphocytes. {ECO:0000269|PubMed:8676067, ECO:0000269|PubMed:9389643}.
|
| Top Pathways |
HTLV-I infection
|