Gene Symbol | Adam10 |
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Entrez Gene | 11487 |
Alt Symbol | 1700031C13Rik, MADM, kuz, kuzbanian |
Species | Mouse |
Gene Type | protein-coding |
Description | a disintegrin and metallopeptidase domain 10 |
Other Description | ADAM 10|a disintegrin and metalloprotease domain (ADAM) 10|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease |
Swissprots | O35598 B8JJJ0 |
Accessions | ABV24058 EDL26211 O35598 AF011379 AAC53303 AK006577 AK031857 AK036599 BAC29502 AK036883 BAC29620 AK036918 AK217253 BC057346 BC066207 AAH66207 BC168390 AAI68390 CB847361 XM_011242657 XP_011240959 NM_007399 NP_031425 |
Function | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP) at '687- Lys-|-Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10- processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO: |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Alzheimer's disease |
Anti-ADAM10 antibody [7H12] - ab194635 from Abcam
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Caronte Antibody [Unconjugated] - AF1051 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) - NBP2-12015 from Novus Biologicals
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ADAM10 Antibody (139712) [Alexa Fluor 700] - FAB946N from Novus Biologicals
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ADAM10 Antibody (139712) [Allophycocyanin] - FAB946A from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [Alexa Fluor (R) 700] - NBP2-12015AF700 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [Alexa Fluor (R) 647] - NBP2-12015AF647 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [Alexa Fluor (R) 488] - NBP2-12015AF488 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [Alexa Fluor (R) 405] - NBP2-12015AF405 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [PerCP] - NBP2-12015PCP from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [DyLight 350] - NBP2-12015UV from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [DyLight 405] - NBP2-12015V from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [PE] - NBP2-12015PE from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [7C] - NBP2-12015V2 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [DyLight 488] - NBP2-12015G from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [DyLight 405LS] - NBP2-12015V3 from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [DyLight 755] - NBP2-12015IR from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [Allophycocyanin] - NBP2-12015APC from Novus Biologicals
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ADAM10 Antibody (RM0146-7H12) [DyLight 680] - NBP2-12015FR from Novus Biologicals
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ADAM10 antibody [7H12] - GTX53236 from GeneTex
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Anti -ADAM10 (ADAM-10 A Disintegrin and Metalloproteinase Domain 10) - 216110 from USBiological Life Science
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ADAM10 (Mouse) - GT15079 from Neuromics
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ADAM-10, Monoclonal Antibody - MBS690356 from MyBioSource
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Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) - PAA766Mu01 from Cloud-clone
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Polyclonal Antibody to A Disintegrin And Metalloprotease 10 (ADAM10) - PAA766Mu02 from Cloud-clone
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