| Gene Symbol | Adam10 |
|---|---|
| Entrez Gene | 11487 |
| Alt Symbol | 1700031C13Rik, MADM, kuz, kuzbanian |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | a disintegrin and metallopeptidase domain 10 |
| Other Description | ADAM 10|a disintegrin and metalloprotease domain (ADAM) 10|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease |
| Swissprots | O35598 B8JJJ0 |
| Accessions | ABV24058 EDL26211 O35598 AF011379 AAC53303 AK006577 AK031857 AK036599 BAC29502 AK036883 BAC29620 AK036918 AK217253 BC057346 BC066207 AAH66207 BC168390 AAI68390 CB847361 XM_011242657 XP_011240959 NM_007399 NP_031425 |
| Function | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP) at '687- Lys-|-Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10- processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO: |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Alzheimer's disease |