Adam10

Gene Symbol	Adam10
Entrez Gene	11487
Alt Symbol	1700031C13Rik, MADM, kuz, kuzbanian
Species	Mouse
Gene Type	protein-coding
Description	a disintegrin and metallopeptidase domain 10
Other Description	ADAM 10|a disintegrin and metalloprotease domain (ADAM) 10|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease
Swissprots	O35598 B8JJJ0
Accessions	ABV24058 EDL26211 O35598 AF011379 AAC53303 AK006577 AK031857 AK036599 BAC29502 AK036883 BAC29620 AK036918 AK217253 BC057346 BC066207 AAH66207 BC168390 AAI68390 CB847361 XM_011242657 XP_011240959 NM_007399 NP_031425
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP) at '687- Lys-|-Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10- processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:
Subcellular Location	Membrane; Single-pass type I membrane protein.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Disintegrin and metalloproteinase domain-containing protein 10, Adam10, Mouse, ELISA Kit - E0766m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Mouse ADAM10 ELISA Kit - MA0734 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse A Disintegrin And Metalloprotease 10 ELISA - E03A0727 from BlueGene Biotech Category ELISA Kit

ELISA Kit for A Disintegrin And Metalloprotease 10 (ADAM10) - SEA766Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 4.3pg/mL. Range 9.375-600pg/mL The standard curve concentrations used for the ELISA's were 600pg/mL, 300pg/mL, 150pg/mL, 75pg/mL, 37.5pg/mL, 18.75pg/mL, 9.375pg/mL

Mouse ADAM10 ELISA Kit - abx153594 from Abbexa Category ELISA Kit Range 9.38 pg/ml - 600 pg/ml

Mouse Adam10 ELISA Kit - E042230 from Biobool Category ELISA Kit

Adam10 High Sensitivity ELISA Kit (Mouse) (OKCD01334) - OKCD01334 from Aviva Systems Biology Category ELISA Kit Prices $555.00 Sizes 96 wells Sensitivity 3.7 pg/mL Range 9.4-600 pg/mL

Mouse ADAM10 ELISA Kit - EMA0734 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

ADAM10 ELISA Kit (Mouse) (OKEH06827) - OKEH06827 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity 0.156 ng/mL Range 0.156-10 ng/mL

Disintegrin and metalloproteinase domain-containing protein 10, ELISA Kit - MBS2885669 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more