| Gene Symbol |
HIC1
|
| Entrez Gene |
3090
|
| Alt Symbol |
ZBTB29, ZNF901, hic-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hypermethylated in cancer 1
|
| Other Description |
hypermethylated in cancer 1 protein|zinc finger and BTB domain-containing protein 29
|
| Swissprots |
D3DTI4 Q14526
|
| Accessions |
AAD09201 CAA07453 EAW90562 EAW90563 EAW90564 Q14526 AJ550616 CAD79467 AJ583693 AJ583694 BC030208 AAH30208 BC156194 AAI56195 BC157027 AAI57028 BQ004706 DQ187313 ABA60890 NM_001098202 NP_001091672 NM_006497 NP_006488
|
| Function |
Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF- responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the partic
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11554746}.
|
| Tissue Specificity |
Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
|