HIC1

Gene Symbol	HIC1
Entrez Gene	3090
Alt Symbol	ZBTB29, ZNF901, hic-1
Species	Human
Gene Type	protein-coding
Description	hypermethylated in cancer 1
Other Description	hypermethylated in cancer 1 protein|zinc finger and BTB domain-containing protein 29
Swissprots	D3DTI4 Q14526
Accessions	AAD09201 CAA07453 EAW90562 EAW90563 EAW90564 Q14526 AJ550616 CAD79467 AJ583693 AJ583694 BC030208 AAH30208 BC156194 AAI56195 BC157027 AAI57028 BQ004706 DQ187313 ABA60890 NM_001098202 NP_001091672 NM_006497 NP_006488
Function	Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF- responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the partic
Subcellular Location	Nucleus {ECO:0000269|PubMed:11554746}.
Tissue Specificity	Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HIC1 peptide - ab33028 from Abcam Category Peptide

Human HIC1 protein fragment - ab114655 from Abcam Category Protein Source Wheat germ Species Human

HIC1 Antibody Blocking Peptide - LS-E2997 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIC1 Antibody Blocking Peptide - LS-E11453 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIC1 Antibody Blocking Peptide - LS-E11145 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIC1 Antibody Blocking Peptide - LS-E13977 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIC1 Antibody Blocking Peptide - LS-E27958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIC1 Antibody Blocking Peptide - LS-E27957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HIC1 Protein - H00003090-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HIC1-Antibody-C-term-Blocking-peptide - BP14127b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIC1 Peptide - AC21-2899-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HIC1 Peptide - AC21-2900-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HIC1 / ZBTB29 - H00003090-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

HIC1 / ZBTB29 - H00003090-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HIC1 / ZBTB29 - H00003090-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HIC1 fusion protein - ag21849 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HIC1 - HIC1-29312TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Hypermethylated in cancer 1 protein(HIC1) - CSB-YP623921HU CSB-EP623921HU CSB-BP623921HU CSB-MP623921HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HIC1 / ZBTB29 (transcript variant 1) - TP322752 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HIC1, Peptide - MBS428615 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

HIC1, Peptide - MBS427997 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig

HIC1 Recombinant Protein Antigen - NBP1-80607PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HIC1 Peptide, Human - M34GP06984H from Creative Peptides Category Peptide Source Synthetic. Species Human

Hypermethylated in cancer 1 protein (HIC1), Recombinant Protein - MBS1442716 from MyBioSource Category Protein Prices $1,545.00, $1,545.00, $1,770.00, $1,770.00, $2,655.00, $2,655.00, $3,095.00, $3,095.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more