HIC1

Gene Symbol	HIC1
Entrez Gene	3090
Alt Symbol	ZBTB29, ZNF901, hic-1
Species	Human
Gene Type	protein-coding
Description	hypermethylated in cancer 1
Other Description	hypermethylated in cancer 1 protein|zinc finger and BTB domain-containing protein 29
Swissprots	D3DTI4 Q14526
Accessions	AAD09201 CAA07453 EAW90562 EAW90563 EAW90564 Q14526 AJ550616 CAD79467 AJ583693 AJ583694 BC030208 AAH30208 BC156194 AAI56195 BC157027 AAI57028 BQ004706 DQ187313 ABA60890 NM_001098202 NP_001091672 NM_006497 NP_006488
Function	Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF- responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the partic
Subcellular Location	Nucleus {ECO:0000269|PubMed:11554746}.
Tissue Specificity	Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HIC-1 (H-6) - sc-271499 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

HIC-1 (D-17) - sc-10318 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIC-1 (N-19) - sc-10317 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIC-1 (H-123) - sc-28703 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-HIC1 antibody - ab33029 from Abcam Prices $372.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HIC1 antibody - ab49326 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 antibody - ab116557 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (clone 4E11) - LS-C197409 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4E11

Anti-HIC1 Antibody (aa497-527, AP) - LS-C258450 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa497-527, APC) - LS-C258451 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa497-527, Biotin) - LS-C258452 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa497-527, FITC) - LS-C258453 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa497-527, Azide-free, HRP) - LS-C258454 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa497-527, PE) - LS-C258455 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa209-258) - LS-C30180 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa497-527) - LS-C321948 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa215-264) - LS-C109624 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa899-948) - LS-C110323 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa498-527) - LS-C166863 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HIC1 Antibody (aa396-410) - LS-C186512 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-HIC1 Antibody (aa193-204) - LS-C186511 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

HIC1 Antibody - NBP1-80607 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIC1 Antibody (4E11.) - H00003090-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4E11.

HIC1 Antibody (2F9) - H00003090-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2F9

HIC1 Antibody (1E11) - H00003090-M03 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E11

Search more